摘要
目的:明确左炔诺孕酮紧急避孕(LNG-EC)暴露是否对妊娠晚期胎盘产生相关影响。方法:选择21例末次月经后使用过LNG-EC药孕妇计划剖宫产的产后胎盘为研究组,21例正常妊娠孕产妇计划剖宫产的产后胎盘为对照组。采用电子显微镜观察胎盘绒毛和细胞器超微结构;采用免疫组织化学方法检测孕妇胎盘中雌激素受体(ER)、孕激素受体(PR)、雄激素受体(AR)和增殖核抗原Ki67、凋亡相关分子caspase-3/8/9的表达情况。结果:光学显微镜和电子显微镜下胎盘形态学组间无统计学差异(P>0.05);胎盘中ER、PR、AR、Ki67和caspase-3/8/9的表达组间无显著统计学差异(P>0.05)。结论:左炔诺孕酮用于紧急避孕不影响其失败后妊娠晚期胎盘的形态结构、性激素受体表达和胎盘增殖及老化。
Objective： To evaluate the impact of exposure to levonorgestrel-only emergency contraception （LNG-EC） on late pregnancy placenta. Methods： Twenty-one samples of placenta tissues were collected from women who used the LNG-EC after last menstrual period （study group）, 21 cases of normal pregnant placenta were collected as control group. Electron microscope was used to investigate the micromorphology configuration, immunohistochemistry was used to investigate the function of the LNG-EC exposed placentas with PR, ER, AR, Ki67 and caspase-3/8/9. Results： There was no significant difference between study group and control group in placenta morphologic examination. The expressions of ER, PR, AR, Ki67 and caspase-3/8/9 in placenta between the two groups were not statistically different. Conclusion： There was no association between the use of levonorgestrel emergency contraception pills and the morphologic configuration in their later pregnancy placenta, LNG-EC does not interfere the main steroid hormone receptors and the aging of placenta.
出处
《生殖与避孕》
CAS
CSCD
2013年第6期394-401,共8页
Reproduction and Contraception
基金
上海市人口和计划生育委员会局管科技发展基金项目<紧急避孕药暴露对子代体格和生殖器官发育的影响>(课题编号2010JG10)和<紧急避孕药物失败后继续妊娠的长期安全性研究>(课题编号2008JG04)资助
