摘要
醛是一类具有高度反应活性的毒性物质,在生物体中主要由膜脂过氧化、氨基酸氧化和蛋白质糖基化产生。醛脱氢酶基因(aldehyde dehydrogenase,ALDH)编码一类将醛脱氢氧化为相应羧基酸的酶,在植物、动物和微生物中均有发现。由于ALDH能够清除毒性醛类物质,其在人体和酵母细胞中已经被详细研究。ALDH基因可划分24个家族,植物中的ALDH基因家族包括ALDH2、ALDH3、ALDH5、ALDH6、ALDH7、ALDH10、ALDH11、ALDH12、ALDH18、ALDH19、ALDH21、ALDH22、ALDH23和ALDH24,有必要对植物中ALDH基因的研究状况做一综述。
Aldehydes are one kind of toxic substance with high activity of chemical reactions. In the body of organism, aldehydes are chiefly generated by the lipid peroxidation, amino acid oxidation, and protein glycation. Aldehyde dehydrogenases （ALDI1） encode one kind of proteins responsible for the oxidation of aldehyde to carboxylic acid, which can be found in plants, animals, and microorganism. As scavenger of toxic aldehydes, ALDH in yeast and human have been investigated thoroughly. ALDH can be classified into 24 families, of which ALDH2, ALDH3, ALDH5, ALDH6, ALDH7, ALDHIO, ALDH11, ALDH12, ALDH18, ALDH19, ALDH21, ALDH22, ALDH23, and ALDH24 can be found in plants. It is necessary to review the current advances on ALDH family in plants.
出处
《生命的化学》
CAS
CSCD
2013年第3期299-306,共8页
Chemistry of Life
基金
云南省自然科学基金项目(KKSA201126058)
