摘要
以4-羟基-3-乙氧基苯胺为原料,先与乙氧亚甲叉丙二酸二酯缩合、再与溴癸烷成醚得到2-（3-乙氧基-4-正癸氧基苯胺基）亚甲基丙二酸二乙酯,总收率为89.2%。缩合反应在无溶剂条件下进行;癸烷基化反应通过加水催化,严格控制反应体系的含水量在2.0%~5.0%,不仅可以加快反应速率,而且提高了转化率,避免了催化剂使用,是一条适合生产的新合成工艺路线。
3-Ethoxy-4-n-decyloxy-anilionmethylene-malonic was prepared from 4-hydroxy-5-ethoxyaniline via condensation and etherification in an overall yield of 89.2%.The condensation was conducted in solvent-free solution and the etherification was catalyzed by 2.0%~5.0% of water,which accelerated the reaction speed and increased the conversion.Furthermore,it avoided using the expensive catalyst such as NaI and KI.This novel synthesis route was suitable for large-scale production as it resulted in a simple work-up process and less usage of organic solvent.
出处
《精细化工中间体》
CAS
2013年第2期55-57,共3页
Fine Chemical Intermediates
