摘要
目的:探讨无抽搐电休克治疗(MECT)对抑郁症患者视觉P300的影响。方法:首发抑郁症患者(抑郁症组)40例和正常对照组40名。正常对照只行视觉P300检测,抑郁症组在MECT前后行视觉P300检测及HAMD评分;两组间进行P300指标比较及对抑郁症组MECT前后视觉P300与HAMD评分进行相关分析。结果:与正常对照组比较,治疗前抑郁症组N2、P3潜伏期延长(t=3.36,8.38;P<0.01),P3波幅降低(t=2.68,P<0.01);治疗后抑郁症组N2、P3潜伏期较治疗前显著缩短(t=2.01,2.98;P<0.01)。相关分析显示,HAMD评分与N2、P3潜伏期治疗前(r=0.89,0.88)和治疗后(r=0.85,0.80)均呈高度正相关(P均<0.01);与N2、P3波幅治疗前(r=-0.13,-0.16)和治疗后(r=-0.18,-0.23)呈微弱负相关(P均>0.05)。结论:MECT可改善首发抑郁症患者视觉P300的各项指标。
Objective：To investigate the effect of modified electroconvulsive therapy（ MECT） on visual-P300 in first-onset depression patients. Method：The eligible subjects were divided into the normal control group （ n = 40） and the depression group （ n = 40） . 40 normal controls were only detected the visual-P300,and 40 depression patients were detected both the visual-P300 and Hamilton depression scale（ HAMD） scores before and after MECT. To explore the differences of visual-P300 between the two groups and the changes of visual-P300 and HAMD scores of depression patients before and after MECT,and then to analyze the correlation between the the changes of latter two items. Results：Compared with normal control group,the N2 and P3 latency was significantly delayed （ t = 3. 36,8. 38; P 0. 01 ） and the P3 amplitude was significantly decreased （ t =2. 68,P 0. 01） in depression group. After MECT,the N2 and P3 latency of the depression group was significantly shorten（ t = 2. 01,2. 98; P 0. 01） . Bivariate correlation analysis showed that the HAMD scores were highly positive correlated with the latency of N2 and P3 no matter before or after treatment （ before treatment r = 0. 89,0. 88; P 0. 01; after treatment r = 0. 85,0. 80; P 0. 01） ; and had a weak negative correlation with the amplitude of N2 and P3（ before treatment r = - 0. 13,- 0. 16; P 0. 05; after treatment r = - 0. 18,- 0. 23; P 0. 05） . Conclusion：MECT can improve the indexs of visual-P300 in depression patients.
出处
《临床精神医学杂志》
2013年第3期203-204,共2页
Journal of Clinical Psychiatry
