摘要
目的评价丁苯酞软胶囊联合盐酸美金刚治疗伴有精神行为症状(BPS)的阿尔茨海默病(AD)的临床疗效及安全性。方法将来自本院的60例伴有BPS的AD患者随机分为对照组及观察组,对照组给予盐酸美金刚治疗,观察组给予丁苯酞联合盐酸美金刚治疗。共观察12 w。采用痴呆行为量表(BEHAVE-AD)评价精神行为症状,简易智能状态基表(MMSE)判定认知功能,日常生活能力量表(ADL)用于判定日常生活活动能力。结果治疗后观察组BEHAVE-AD、MMSE及ADL评分均明显优于对照组(P<0.05);在精神行为方面,观察组全部患者BEHAVE-AD评分<8分,说明观察组患者精神行为症状基本控制;在认知方面,特别是记忆、注意及言语能力方面,观察组进步明显优于对照组(P<0.05);在日常生活能力方面,特别是上厕所、进食、穿衣、梳洗、行走和洗澡方面,观察组进步明显优于对照组(P<0.05);两组患者均未出现明显不良反应患者。结论应用丁苯酞联合盐酸美金刚治疗伴有BPS的AD,疗效较单独使用盐酸美金刚好,不增加毒副作用,有进一步临床推广价值。
Objective To evaluate the clinical therapeutic effects and safety of butylphthalide soft capsules combined with memantine hydrochloride on behavioral and psychological symptoms（BPS） in patients with Alzheimer disease（AD）.Methods Sixty AD patients with BPS were randomly divided into control group and observation group.The control group received the treatment with memantine hydrochloride,while the observation group received the treatment with memantine hydrochloride combined with butylphthalide soft capsule.Observation was made for 12 weeks.The mental and behavioral symptoms were evaluated by BEHAVE-AD.The cognitive function was evaluated by MMSE.The ability of daily living activities was evaluated with ADL.Results After the treatment,BEHAVE-AD,MMSE,and ADL scores of the observation group were significantly better than those of the control group（P 0.05）.In the aspect of mentality and behavior,the BEHAVE-AD scores of the patients in the observation group were lower than 8 scores,which indicated that the mental and behavioral symptoms of these patients were basically under control.In the aspect of cognition,especially the abilities of memory,attention,and language,the improvements of the observation group were significantly better than that of the control group（P 0.05）.In the abilities of daily living,especially in the aspects of going to lavatory,eating,putting on closes,washing up,walking,and taking a shower,the improvements of the observation group were significantly better than those of the control group（P 0.05）.Adverse reactions did not occur in the patients of the two groups.Conclusion The treatment of mental and behavioral disorder in patients with AD with butylphthalide and memantine hydrochloride has a better curative effect than simple memantine hydrochloride.
出处
《西南国防医药》
CAS
2013年第6期619-621,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
丁苯酞软胶囊
美金刚
阿尔茨海默病
疗效
butylphthalide soft capsule
memantine
Alzheimer disease
curtive effect
