摘要
目前研究已证实勃起功能障碍(ED)和良性前列腺增生(BPH)之间除了有高龄等共同危险因素外,在流行病学上也具有相关关系。虽然目前的研究尚不能得出直接的因果关系,但包括一氧化氮生物利用度改变,自主神经系统和α1受体功能亢进,RhoA/Rhod激酶通路异常及代谢综合征等多种因素在ED和BPH的发病中均起到重要作用。因此对BPH患者进行评估治疗时,应同时筛查性功能指标,判断是否同时合并有ED。多项临床研究发现他达拉非等PDE5抑制剂在ED合并BPH相关下尿路症状的治疗中效果良好,这为进一步研究ED合并BPH的治疗和预防奠定了基础。
Epidemological studies have confirmed that benign prostatic hyperplasia （BPH） and erectile dysfunction （ED） are correlated, independent of age or comorbidities as diabetes. Although researchers have not yet established a direct causal relationship between the two problems, several pathophysiological factors may serve to explain it, which include the alteration in nitric oxide bioavailability, increased autonomic activity, al-adrenergic receptor hyperactivity, imbalance of RhoA/Rho-kinase, and metabolic syndrome X. Men seeking care for BPH should always be screened for sexual function and complaints of ED. PDE5 inhibitors show promise as a future treatment for lower urinary tract symptoms secondary to BPH. Further investigation is required for future therapies and possible preventative strategies.
出处
《中华男科学杂志》
CAS
CSCD
2013年第6期572-575,共4页
National Journal of Andrology
