摘要
利用溶液聚合法制备了壳聚糖-聚甲基丙烯酸(CS-PMAA)聚电解质纳米粒子,并对其组成和形态进行了表征.红外光谱(FT-IR)和X射线衍射谱图(XRD)证明了聚电解质复合物的形成,结合自动电位滴定和电导率滴定确定了CS-PMAA的实际的氨基/羧基含量,动态光散射(DLS)和透射电镜(TEM)数据表明成功合成了分散液较好的纳米颗粒,同时研究了pH值对粒径的影响.数据表明,所合成的纳米粒子具有较高的pH响应性.pH=5左右粒径在180nm左右,在pH=3和9时粒径较大,在强酸和强碱性的条件下(pH<3和pH>9),粒径又逐渐减小.由于合成的粒子粒径较小且结构均一,具有较高的pH敏感性和良好的生物相容性,在生物领域具有广泛的应用前景.
Chitosan-polymethylacrylic acid （CS-PMAA） polyelectrolyte nanoparticles were prepared by solution polymerization, the compositions and morphology were determined. FT-IR and XRD patterns confirmed the formation of polyelectrolyte composites, the experimental compositions for --NH2/-- COOH of CS-PMAA were determined by automatic potentiometric titration and conductivity titration. DLS and TEM studies show that the nanoparticles are well dispersed and the dependence of particle size on pH values is observed. The results show that the nanoparticles have a high pH responsibility. The particle sizes are about 180 nm at pHzS, increase at pH of 3 and 9 and decrease at extreme pH values （pHi3 and pHi9）. They have a broad perspective in application due to its small grain size, uniform structure, high pH responsibility and good biocompatibility.
出处
《中北大学学报（自然科学版）》
CAS
北大核心
2013年第3期275-279,共5页
Journal of North University of China(Natural Science Edition)
基金
山西省自然科学基金资助项目(2010011032-4)
太原市科技明星资助项目(120247-25)
