摘要
目的探讨急性脑梗死患者颈动脉粥样硬化斑块的稳定性与血管内皮功能的相关性。方法应用颈动脉彩色多普勒超声技术检查研究对象颈动脉粥样硬化斑块的大小、数目及性质。选取血管性假血友病因子(Von Willebrand factor,vWF)与可溶性血管内皮细胞蛋白C受体(Soluble endothelial protein C receptor,sEPCR)作为急性脑梗死患者血管内皮功能的评价指标。采用ELISA方法检测其血浆中vWF与sEPCR含量。根据颈动脉彩超的结果,将急性脑梗死患者分为不稳定性斑块脑梗死组、稳定性斑块脑梗死组,并选取健康对照组,组间比较采用独立样本t检验,并行简单相关分析。结果不稳定性斑块脑梗死组血浆中vWF与sEPCR含量显著高于稳定性斑块脑梗死组(P<0.001),急性脑梗死患者颈动脉粥样硬化斑块的稳定性与vWF及sEPCR呈负相关(P<0.001)。结论急性脑梗死患者血管内皮功能损伤越严重,则颈动脉粥样硬化斑块可能越不稳定。
Objective To probe the relativity between stability of carotid atherosclerotic plaques and vascular endothelial function in patients with acute cerebral infarction.Methods we detected the size,number and nature of carotid atherosclerotic plaques of patients with acute cerebral infarction by Color Doppler Ultrasound.Selected vWF and sEPCR as the evaluation index which evaluate endothelial function in patients with cerebral infarction.Detected the plasma vWF and sEPCR levels by ELISA.Divided the patients with acute cerebral infarction into unstable plaque cerebral infarction group,stable plaque cerebral infarction group and control group by the result of carotid ultrasonography.Groups were compared using independent samples t test and simple correlation analysis.Results The plasma vWF and sEPCR levels in unstable plaque cerebral infarction group were significantly higher than stable plaque cerebral infarction group.The stability of carotid atherosclerotic plaques show a nagtive correlation with vWF and sEPCR in patients with acute cerebral infarction.Conclusion Endothelial dysfunction in patients with acute cerebral infarction is more severe,carotid atherosclerotic plaque may be more unstable.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2013年第5期422-424,共3页
Journal of Apoplexy and Nervous Diseases
关键词
急性脑梗死
颈动脉粥样硬化斑块
易损斑块
血管性假血友病因子
可溶性血管内皮细胞蛋白C受体
Acute cerebral infarction
Carotid atherosclerotic plaques
Unstable carotid atherosclerotic plaques
Von Willebrand factor
Soluble endothelial protein C receptor
