摘要
目的:观察应用配对血浆滤过吸附(CPFA)联合高容量血液滤过(HVHF)治疗重症胰腺炎时对血清细胞因子水平的影响。方法:将29例SAP患者随机分为两组,采用前瞻性随机对照研究,在常规治疗基础上,治疗组(15例)采用CPFA+HVHF治疗,对照组(14例)采用HVHF治疗,所有患者均在重症监护中。比较治疗前后两组患者的TNF-α、IL-1β、IL-6、IL-10、白细胞、APACHEⅡ评分及临床症状改善情况。结果:两组治疗后患者的APACHEII评分、白细胞明显下降(P<0.01),促炎因子水平下降,抗炎因子水平上升,尤以治疗组效果明显,同一治疗组治疗7d时的效果优于3d,差异有统计学意义,治疗组的住院时间短于对照组(P<0.05)。结论:CPFA联合HVHF能更有效地调控炎症因子水平,提示CPFA联合HVHF治疗SAP有更广阔的前景。
Objective To observe the clinical effects of coupled plasma filtration adsorption （CPFA） combined with high volume hemofihration （HVHF） on serum levels of eytokines in patients with severe acute pancreatitis （SAP）. Methods 29 patients with SAP in ICU （intensive care unit） were involved in this study and were divided into 2 groups. All patients received conventional therapy, and those in treatment group （15 cases） received CPFA ＋ HVHF therapy, whilst those in control group （14 cases） received HVHF therapy. Comparative analysis on APACHE H grade, serum levels of TNF-α, IL-1β, IL-6, IL-10, WBC counting and the improvement of clinical symptoms before and after treatment were administered. Results After treatment, APACHE Ⅱ grade, WBC counting, serum levels of TNF-α, IL-1β, IL-6 were significantly decreased （P 〈 0.01）, while IL-10 was increased, in both groups. But those in treatment group were more obvious. The length of hospital stay in treatment group was less than that in control group. Conclusion CPFA combined with HVHF could more effectively control inflammation and improve the prognosis of patients with SAP.
出处
《实用医学杂志》
CAS
北大核心
2013年第12期1947-1950,共4页
The Journal of Practical Medicine
关键词
配对血浆滤过吸附
高容量血液滤过
急性重症胰腺炎
细胞因子
Coupled plasma filtration adsorption
High volume hemofihration
Severe acute pancreatitis
Cytonkines
