摘要
通过溶液聚合制备了一种新型不饱和聚磷酸酯(PolymerⅠ),经季铵化得到了侧基含季铵基的不饱和聚磷酸酯(PolymerⅡ).对聚合物的结构和热性能进行了表征.研究了PolymerⅡ与聚丁二酸丁二醇酯(PBS)的共混片基(PolymerⅡ的质量分数分别为5%,10%和20%)在pH=7.4的磷酸缓冲溶液中的溶胀和降解性能.结果表明,以纯三甲胺为季铵化试剂,在V(氯仿)∶V(异丙醇)∶V(DMF)=3∶5∶5的混合溶剂中,于60℃反应24 h可得到季铵化率高达48%的PolymerⅡ.在PBS中PolymerⅡ的含量越多,达到溶胀平衡时,共混片基的溶胀率越高,越容易降解.磷酸酯的引入使聚合物的熔点(Tm)和热稳定性(Td)降低.
A new biodegradable and biocompatible unsaturated polyphosphoester bearing quaternary ammonium pendent groups was synthesized and characterized by 1 H NMR,FTIR,gel permeation chromatography（GPC） and elemental analysis.Physical properties of the synthesized polymers were also characterized by means of thermal analysis,in vitro degradation and swelling behavior.The experimental evidence demonstrated that the introduction of quaternary ammonium pendent groups reduced the melting point and the decomposition temperature of polyphosphoester.The experiments of in vitro degradation and swelling behavior revealed that the more polyphosphoester in the polymer tablets,the faster degradation rates and the higher swelling ratio.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2013年第6期1555-1559,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21004048)、中国博士后基金(批准号:2012M512021)和陕西省教育厅项目(批准号:2010JK886)资助
