摘要
目的:观察加味胸痹汤对冠心病心绞痛患者TNF-α、VEGF水平的影响,探讨在冠心病发病中的部分可能机制。方法:将60例冠心病稳定型心绞痛患者随机分成治疗组和对照组,每组各30例,两组均根据病人病情选用ACE抑制剂、β受体阻滞剂、抗血小板聚集等最优化的西药治疗;治疗组在以上治疗的基础上加用中药加味胸痹汤口服,疗程结束后观察疗效与结果。结果:两组治疗后中医证候疗效改善情况比较有统计学差异,P<0.05,但心电图的改善情况无统计学意义。治疗组治疗后的TNF-α含量明显低于西药对照组治疗后,(P<0.05),中药治疗组血清VEGF的含量较治疗前明显升高(P<0.05),而西药对照组血清VEGF的含量较治疗前升高不明显(P>0.05)。结论:中药加味胸痹汤可以提高中医证候疗效,本方有抑制血管内皮炎性细胞分泌TNF-α,保护血管内皮功能的作用。对促进血管内皮细胞分泌VEGF具有明显的作用,从患者症状明显改善甚至消失,推测该药可能有促进缺血心肌血管新生的作用,这可能是该药对于缺血心肌保护作用机制之一。
Objective ： To observe the effect of Xiongbi Decoction on TNF - a and VEGF levels of coronary heart disease patients with angina pectoris, and to explore the possible mechanisms in the pathogenesis of coronary heart disease. Methods ： 60 cases of coronary heart disease in patients with stable angina were randomly divided into treatment group and control group, 30 in each group, based on the patients＇conditions, ACE inhibitors, β -blockers, anti- platelet aggregation optimization were selected. Treatment group on the basis of the above treatment added with the Xiongbitong Decoction. The effects were observed after treatment. Results： After treatment, TCM syndrome was improved with statistical difference （ P 〈 0.05 ）, but there was no statistically significant ECG improvement. After treatment, TNF - a level was significantly lower than that of the comparison group （ P 〈 0.05 ）, treatment group serum levels of VEGF were significantly increased （ P 〈 0.05 ）, while the serum VEGF content in control group was not obviously increased （ P 〉 0.05 ）. Conclusion ： Xiongbitong Decoction can improve the TCM syndromes, the party inflammatory ceils to inhibit vascular endothelial secretion of TNF -a, and protect the role of vascular endothelial function. The promotion of vascular endothelial cells to secrete VEGF has a distinct role, speculating that the drug may have a role to promote myocardial angiogenesis, which may be one of the mechanisms of the protective effect of the drug for ischemic myocardium.
出处
《中华中医药学刊》
CAS
2013年第6期1446-1449,共4页
Chinese Archives of Traditional Chinese Medicine
