摘要
目的探讨早产儿甲状腺功能低下的危险因素、临床表现、类型及治疗效果,为临床提供诊治依据。方法对2010年8月～2012年8月于本院新生儿科住院治疗的106例诊断甲状腺功能低下的早产儿资料进行回顾性分析。结果双胎、新生儿窒息、妊娠期糖尿病、新生儿呼吸窘迫综合征等高危因素存在于这些患儿中。临床表现有呼吸暂停、黄疸时间延长、喂养不耐受等。大胎龄组患儿易出现水肿表现。各种类型中以暂时性低甲状腺素血症多见,其它还有暂时性甲状腺功能减退、低T3综合征、高TSH血症等类型。大胎龄组患儿易表现为低T3综合征。小剂量左甲状腺素钠片治疗有效,且大胎龄组患儿对治疗更敏感。结论早产儿甲状腺功能低下发病率高,并且不能通过新生儿筛查及时发现。应在生后1～2周对早产儿进行甲状腺功能检查、及时干预。
Objective To investigate the risk factors, clinical manifestations, classifications and treatment outcomes of premature infants suffering from thyroid hypofunction. Methods 106 preterm babies in our hospital during August 2010 to August 2012 suffering from thyroid hypofunction were retrospective analyzed. Results Twins, neonatal asphyxia, gestational diabetes mellitus, neonatal respiratory distress syndrome（NRDS） , et al, are existed in these patients as risk factors. Main clinical manifestations include apnea, prolonged jaundice, feeding intolerance, et al. The older gestational age babies manifest edema more often. There are transient thyroid hypofunction, transient hypothyroxinaemia, low-T3 syndrome and byperthyrotropinemia 4 common types of thyroid hypofunction showed in our study. The older gestational age babies are easier suffering from low-T3 syndrome. L-T4 treatment is effective, and the older gestational age babies are more sensitive. Conclusion The morbidity of hypothyroidism is high in premature babies while the congenital hypothyroidism screening shows negative result. It＇s necessary for preterm infants to take the thyroid function test 1 - 2 weeks after birth, and be treated on time if the result is positive.
出处
《四川医学》
CAS
2013年第4期440-442,共3页
Sichuan Medical Journal
基金
四川省科技厅科技支撑项目(编号:2011sz0161)
关键词
早产儿
甲状腺功能低下
高危因素
治疗
premature infant
thyroid hypofunction
risk factor
treatment
