摘要
目的 研究带血管自体骨膜 (VAP)与同种脱钙骨基质 (DHBM )移植修复大段骨缺损的生物力学特征。方法 以兔双侧桡骨中段 2 5mm的骨缺损为模型 ,测试了VAP +DHBM移植和自体骨移植后桡骨的最大扭距 (Mnmax)和抗扭刚度 (GIP)。结果 术后 4、8、12周VAP +DHBM侧及自体骨移植侧的Mnmax和GIP均低于正常桡骨 (P <0 .0 1) ;术后 16周两侧GIP与正常桡骨已无差异 (P >0 .0 5 ) ,但Mnmax仍低于正常 (P <0 .0 1) ;术后 2 0周两侧的Mnmax和GIP与正常桡骨均无差异 (P <0 .0 5 )。结论 在节段性骨缺损修复中 ,无论是VAP +DHBM移植还是自体骨移植 ,其力学性能的恢复都是渐进性的 ,且愈合刚度的恢复快于愈合强度的恢复。VAP +DHBM移植的效果可以与自体骨移植相媲美 ,移植后VAP和DHBM之间建立了相互协同、相互促进的关系。
Objective To explore the biomechanical property of the healing of large segmental bone defect grafted with vascularized autogenous periosteum(VAP) associated with demineralized homologous bone matrix (DHBM). Methods The effect of VAP+DHBM graft and autogenic bone graft on the healing of a 25 mm diaphysial defect in the radius was studied by biomechanical torsional test and x-ray examination for the maximam torque(Mnmax) and torsional stiffness (GIP).Results After 4,8,12 weeks of the graft,Mnmax and GIP in both VAP+DHBM and autogenous bone graft sides were lower than those of the normal radius (P< 0.01 ).Then after 16 weeks,GIP in both sides showed little difference with the normal (P> 0.05 ),but Mnmax still remained lower (P< 0.01 ).Consequently after 20 weeks Mnmax and GIP in both sides proved proximity to the normal (P< 0.05 ).Conclusion In the segmental bone defect-repair,no matter by VAP+DHBM or by autogenous bone graft,the biomechanical recovery is gradual with stiffenss improvement abead of strength.VAP+DHBM proves as good as autogenous bone graft as the two established mutual combination and stimulation.
出处
《中华物理医学与康复杂志》
CSCD
2000年第3期145-147,共3页
Chinese Journal of Physical Medicine and Rehabilitation
