摘要
【目的】探讨右美托咪定用于接受机械通气早产儿镇静、镇痛的有效性与安全性。【方法】选取新生儿科中接受机械通气早产儿120例，随机均分为右美托咪定组（D组）、咪达唑仑组（M组）、芬太尼组（F组），每组40例。比较三组患儿的镇静、镇痛效果，血流动力学变化情况及短期预后情况。【结果】D组接受机械通气的早产儿在使用右美托咪定后，其早产儿疼痛评分降低，血流动力学稳定，与M组、F组相比较无显著差异（P〉0．05）。机械通气时间D组低于M组、F组（P〈0．05）；达到足量肠道喂养时间比较，F组高于D组、M组，其差异有显著性（P〈0．05）；三组患儿病死率、气胸、颅内出血发生率相比较差异无显著性（P〉0．05）。【结论】右美托咪定对接受机械通气的早产儿可起到良好的镇静、镇痛作用。
[ObjectivelTo explore the effectiveness and safety of dexmedetomidine used for sedation and analgesia during mechanical ventilation in preterm infants. [Methods]Totally 120 preterm infants receiving mechanical ventilation in neonatal department were chosen and randomly divided into dexmedetomidine group （group D）, midazolam group（group M） and fentanyl group（group F） with 40 patients in each group. The effi- cacy of sedation and analgesia, hemodynamic change and short-term prognosis were compared among 3 groups. [Results] After the treatment with dexmedetomidine, pain scores of preterm infants in group D receiving mechanical ventilation markedly decreased, and the hemodynamics was stable, but there was no significant different between group D and group M and F（ P 〉0.05）. The time of mechanical ventilation in group D was shor- ter than that in group M and F（ P 〈0.05）. Sufficiency enteral feeding time in group F was longer than that in group D and M, and there was significant difference（ P 〈0.05）. There was no significant difference in fatality rate and the incidence of pneumothorax and intracranial hemorrhage among 3 groups（ P 〈0.05）. [Conclusion] Dexmedetomidine is effective for sedation and analgesia during mechanical ventilation in preterm infants.
出处
《医学临床研究》
CAS
2013年第5期927-929,932,共4页
Journal of Clinical Research
关键词
婴儿
早产
呼吸
人工
Infant, Premature
Respiration, Artificial
