摘要
目的考察注射用加替沙星与注射用头孢地嗪钠分别在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法在室温(20±1)℃,观察两药配伍后的外观、pH、含量变化,高效液相色谱法测定配伍液中加替沙星和头孢地嗪钠含量。结果两药配伍后6 h内的外观、pH、含量均无明显变化。结论在室温条件下,注射用加替沙星与注射用头孢地嗪钠在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。
Objective To study the compatibility of gatifloxacin for injection and cefodizime sodium for injection in 0.9% sodium chloride or 5% glucose. Methods An high performance liquid chromatography （HPLC） method was used to study the content changes after mixture of gatifloxacin and cefodizime sodium after storage at room temperature （20± 1 ） ℃ for 6 h. Changes of the physical appearance and the pH in the admixture were also examined. Results No significant change in drug content, pH, or physical appearance was found after 6 h. Conclusion Gatifloxacin for injection can be mixed with cefodizime sodium for injection in 0.9% sodium chloride or 5% glucose.
出处
《医药导报》
CAS
北大核心
2013年第6期793-795,共3页
Herald of Medicine
基金
河北省医学科学研究重点课题(04177)
关键词
加替沙星
头孢地嗪
配伍
稳定性
色谱法
高效液相
Gatifloxacin
Cefodizime
Compatibility
Stability
Chromatography, high performance liquid
