摘要
甲状腺激素能通过基因作用及非基因作用对机体几乎所有组织产生生理调节作用,通常认为甲状腺激素发挥其生理作用是由核受体调节基因转录介导的,但越来越多的证据表明甲状腺激素亦可与细胞膜、胞浆或线粒体内受体结合触发非基因信号作用,快速调节心血管功能。长期以来甲状腺激素的非基因作用对心血管功能的影响极少有人涉及,本文综述甲状腺激素通过非核受体、第二信使及效应蛋白介导的非基因作用对心血管系统的影响,旨在为心血管疾病的有效治疗和药物开发提供新的途径或靶点。
Thyroid hormones play a wide range of important physiological activities in almost all organism.As changes in these hormones levels,observed in hypothyroidism and hyperthyroidism,promote serious derangements of the cardiovascular system,it is important to know their mechanisms of actions.Although the classic genomic actions which are dependent on interaction with nuclear receptors to modulate cardiac myocyte genes expression,there is growing evidence about T3 and T4-triggered nongenomic pathways,resulting from their binding to plasma membrane,cytoplasm,or mitochondrial receptors that leads to a rapid regulation of cardiovascular functions.Disappointedly,little attention is paid to the rapid nongenomic actions of thyroid hormones on cardiovascular system.This paper reviews the effects of thyroid hormones on cardiovascular function via nongenomic actions involving extranuclear receptors,second messengers,or effect proteins.A full understanding of the link between thyroid hormones and cardiovascular functions should be beneficial for appropriate management of cardiovascular diseases by modulating thyroid hormones levels.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2013年第5期586-591,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
甲状腺激素
非基因作用
心血管功能
Thyroid hormones
Nongenomic action
Cardiovascular function
