摘要
探讨补肾活血类中药骨康口服液对维甲酸所造成的骨质疏松的影响。通过给大鼠灌服维甲酸 14d后造成的骨质疏松模型 ,观察了中药骨康口服液对骨质疏松大鼠骨密度 (BMD)、骨矿含量 (BMC)、股骨最大扭矩(M)及血清雌二醇 (E2 )的影响 ,并与特乐定作阳性对照。结果 :中药骨康防治骨质疏松大鼠骨密度、骨矿含量、股骨最大扭矩及血清雌二醇含量高于模型组 (P<0 .0 5、0 .0 1) ,治疗组大鼠 BMD、BMC高于模型组 (P<0 .0 5 )。骨康防治组优于治疗组 (P<0 .0 5 )。结论 :推测骨康能提高骨质疏松大鼠血清 E2 含量、骨的骨矿含量及骨密度 ,改善骨的内部构造 ,从而提高大鼠骨的机械性能 。
Objective:To evaluate anti-osteoporosis effect of Gukang oral liquid(GOL) in rats.Methods:Fifty rats randomly allocated to five groups:control group,model group,tridin group,prevention and treatment of Gukang group,treatment of Gukang group.Results:Torsion moment arm(M) was higher in GOL groups with prevention and treatment of Gukang than that in model group(P<0 05).Bone mineral desity(BMD) and Bone mineral content(BMC) were higher in all GOL groups than that in model group(P<0 05).Conclusion:Suggested that GOL could promote the BMD and BMC in rats with osteoporosis;and could promote the restructure of bone trabecula and improve the bone mechanical function in rats with osteoporosis.
出处
《湖南中医学院学报》
2000年第2期16-17,共2页
Journal of Hunan College of Traditional Chinese Medicine
基金
国家中医药管理局科研基金!项目 (95 B32 11)
