摘要
文章以对羟基苯甲酸和甲醇在离子液体[Hmim]+BF4-催化下反应得到尼泊金甲酯。通过响应曲面法优化了反应的条件,得到尼泊金甲酯合成的最佳工艺:醇与酸的摩尔比为3.25,离子液体投加量为1.4mL(以对羟基苯甲酸为0.1mol为准),反应时间为4h,反应温度为45℃,在此最佳条件下,产率可达90.64%。
Nipagin methyl ester is synthesized by hydroxybenzoic acid and methanol under the catalytic reaction of ionic liquid [Hmim-]＋ BF^-4. Response surface methodology is used to optimize the reaction conditions, the best process of methylparaben synthesis is as follows： the molar ratio of methanol and hydroxybenzoic acid is 3. 25, the dosage of ionic liquid is 1.4 mL （take p-hydroxybenzoic acid of 0.1 tool as basi,.）, the reaction time is 4 h, the reaction temperature is 45 ℃, Under the optimal conditions, the yield is 90.64%.
出处
《中国调味品》
CAS
北大核心
2013年第6期46-50,共5页
China Condiment
关键词
尼泊金甲酯
合成
离子液体
响应曲面法
nipagin methyl ester
synthesis
ionic liquid
response surface methodology
