摘要
[目的]观察中医辨证论治治疗功能性消化不良(FD)的临床效果。[方法]采用随机、双盲、多中心、安慰剂对照临床研究,共收集273例FD患者,根据中医辨证论治将其分为湿热壅滞证、脾虚气滞证、肝胃气滞证和肝胃郁热证,每证分为治疗组、对照组,分别予相应中药配方颗粒、中药模拟剂治疗。[结果]基线资料单项症状比较得出:餐后饱胀症状以湿热壅滞证积分最高(P<0.05),上腹痛症状以肝胃郁热组积分最高(P<0.05)。各证型分组疗效比较得出:脾虚气滞证治疗组14d、28d有效率显著高于对照组(63.3%∶41.9%、80.0%∶41.9%);其他各证型治疗组与对照组比较差异无统计学意义。脾虚气滞证、湿热壅滞证、肝胃气滞证、肝胃郁热证中治疗组与对照组28d治疗前后症状积分均显著改善(P<0.05)。安全性评价各证型中治疗组与对照组均无严重不良反应。[结论]中医辨证论治治疗湿热壅滞证、脾虚气滞证、肝胃气滞证和肝胃郁热证功能性消化不良安全、疗效确切。
[Objective]To study the influence of TCM differentiating treatment on patients with func- tional dyspepsia. [Methods]A randomized, placebo-controlled, double-blinded and multicenter study was conducted. 273 cases were recruited with functional dyspepsia, who were diagnosed as 4 types according to TCM differentiating theory and each type was administered the corresponding herbs and placebo. [Results] Post-prandial fullness syndrome score was highest prominently in the stagnation of damp-heat type. Upper abdominal pain syndrome score was highest in the heat stagnation of liver and stomach type. Efficacy in each type showed that 14 day and 28 day effective rate in the treatment group was significantly higher com- pared to the placebo control group（67.5% vs 54. 5 ~ff0）and（76.2% vs 56.3%）. Effective rate in the treat- ment group of the spleen deficiency and qi stagnancy type was significantly higher compared to the control group, 14 day（63.3% vs 41.9%） ,28 day（80.0% vs 41.9%）. The symptom scores of the treatment group of the spleen deficiency and qi stagnancy, the treatment and placebo group of the stagnation of damp-heattype, qi stasis of liver and stomach type and heat stagnation of liver and stomach type were significantly de- creased compared to those of pre-treatment. [Conclusion] TCM differentiating treatment on patients with functional dyspepsia was effective without obvious adverse effect.
出处
《中国中西医结合消化杂志》
CAS
2013年第5期225-228,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
十一五科技支撑计划功能性消化不良中医辨证论治的规范化方案研究(No.2007BAI20B0901)
关键词
功能性消化不良
中医辨证论治
疗效评价
functional dyspepsia
TCM differentiating treatment
evaluation of efficacy
