摘要
目的 :观察 1 1 0例痴呆及其他神经系统疾病病人脑脊液中 Tau蛋白和 Aβ1 - 4 2 水平的变化 ,对它们的临床意义进行初步的探讨。方法 :用酶联免疫吸附法 (ELISA)对脑脊液中的上述指标进行检测。结果 :Alzheimer病(AD)组的 Tau蛋白水平与其他神经系统疾病相比有明显升高 ,AD组的 Aβ1 - 4 2 水平有明显下降。结论 :Alzheimer病人脑脊液中的 Tau蛋白及 Aβ1 - 4 2 水平与年龄匹配的对照组相比有明显变化 ,但与非
s Objective:To observe the alterations of Tau protien and βamyloid protien 142 in the cerebrospinal fluid(CSF)of 110 cases of dementia and other neurological diseases and to investigate their's dignostic significance clinically.Methods:By sensitive enzymelinked immunosorbent assays,we analyzed the CSF samples.Results:We found significant increase of the Tau protien levels in the AD patients compared with other neurological diseases.The significant decrease of the Aβ 142 levels was observed in the AD patients.Conclusions:The Tau protien and Aβ 142 levels in CSF of AD group varied as compared with that in the agematched controls.However two markers have shown ovelaps in nonADtype dementia and in the other neurological diseases.
出处
《卒中与神经疾病》
2000年第2期81-83,共3页
Stroke and Nervous Diseases
基金
北京市卫生局重点课题
