摘要
分析脑卒中对心室做功的影响以及与高血压的关联性,为卒中和脑心综合症等心脑血管疾病的预警提供血液动力学依据。基于非对称T型管,建立心脑血管耦合的血液动力学模型,计算和分析动脉血液动力学行为;通过提高脑外周阻力和降低血管弹性,数值模拟在大脑动脉血管病变的情况下血压、脑血流量和心室做功功率的变化趋势。研究表明,相对于正常情况,卒中患者其脑外周阻力显著提高,脑阻力达到正常值2倍以上的占统计总人数的83%;其血压(尤其是收缩压和脉压)会明显高于正常值,模拟的收缩压达到140 mmHg以上;其脑部血液流量存在代偿流动和调节;其心室外功的总功率以及振荡功率占总功率的比例均增加,增加幅度达到10%以上。卒中患者的心室做功受到脑血管病变的影响,因而在治疗卒中的同时应加强对心脏的保护。
The aim of this work is to analyze the effect of stroke on the ventricular work and the correlation with hypertension and to provide the hemodynamic evidences for the precaution of stroke and cardiovascular diseases. A dynamic model for heart and cerebrovascular coupling was proposed based on asymmetric T-tube model, and its arterial hemodynamic behaviors were computed and analyzed. Changes of the pressure, cerebral blood flow and ventricular power were simulated by altering the level of cerebral arterial resistance and compliance. Results showed that cerebral peripheral resistance in patients with stroke was significantly higher than that in the normal. The patients whose cerebral peripheral resistance was more than twice of normal value was 83% of the total. Blood pressure in stroke, especially the systolic pressure and the pulse pressure, was significantly higher than that of the normal. The systolic pressure was higher than 140 mmHg according to the simulated results. Compensatory flow and autoregulation existed in cerebral circulation. Ventricular power as well as the proportion of the pulsatile to total power increased with the increment higher than 10%. The cerebral pathological change in stroke was closely associated with hypertension and affected the ventricular work. Thereofore in the treatment of stroke, heart protection should also be strengthened.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2013年第3期321-330,共10页
Chinese Journal of Biomedical Engineering
基金
上海市科技发展基金(09DZ1976600)
上海市重点学科建设项目(B112
T0302)
