摘要
目的观察富含益生菌的酸奶在改善乙肝后肝硬化患者肠道菌群失调、降低发生肝性脑病风险以及提高患者生活质量方面的作用。方法选择乙型肝炎肝硬化患者74例，随机分为常规组38例和酸奶组36例，常规组患者给予保肝、利尿等常规治疗；酸奶组患者在此基础之上增加富含益生菌的酸奶，饭后30min后食用。治疗2周后比较常规组和酸奶组患者慢性肝病问卷评分（CLDQ）、血粪氨含量、粪便pH值以及肠道常见菌群含量。结果治疗后酸奶组患者CLDQ各项目评分均有提高，尤其在腹部症状、焦虑状况以及乏力方面，治疗后CLDQ评分分别为（5．78±0．81），（5．91±0．81），（5．66±0．61）分，治疗前分别为（4．77±0．50），（4．93±0．97），（4．89±0．67）分，治疗前后比较差异有统计学意义（t值分别为3．35，2．46，2．67；P〈0．05）；而常规组无明显变化。酸奶组患者的血氨、粪氨浓度以及粪便pH值均下降；有益菌得到增长，致病菌菌落数减少。结论富含益生菌酸奶可以参与乙肝后肝硬化患者的长期辅助治疗。
Objective To observe the effect of probiotic yogurt in resolving enteric flora imbalance, reducing risks of hepatic encephalopathy and improving life quality of patients with liver cirrhosis after hepatitis B. Methods Totals of 74 patients with liver cirrhosis after hepatitis B were selected and randomly divided into the control group （ n = 38 ） and the yogurt group （ n = 36）. The control group received conventional treatment to protect the liver and promote urination, while the yogurt group had probiotie yogurt 30 minutes after meals in addition. Chronic liver disease questionnaire （CLDQ） score, ammonia content in bloody stool, pH value of dejection and content of common flora were compared between two groups after two weeks of treatment. Results CLDQ score in the yogurt group improved after treatment, especially in abdominal symptoms, anxiety and acratia, which was respectively （5.78 ±0. 81 ）, （5.91 ± 0.81 ） and （5.66 ±0. 61 ） after treatment and （4.77 ± 0.50）, （4.93 ± 0.97 ） and （4.89 ± 0.67 ） before. There were statistically significant differences before and after in the yogurt group （ t = 3.35,2.46,2. 67, respectively; P 〈 0. 05 ）, compared to no statistically significant difference in the control group. Content of blood ammonia and stool ammonia as well as pH value of dejection decreased in the yogurt group. Beneficial bacterium had grown and harmful bacteria had dropped. Conclusions Probiotic yogurt can take part in the long-term adjuvant treatment of patients with liver cirrhosis after hepatitis B.
出处
《中华现代护理杂志》
2013年第12期1395-1398,共4页
Chinese Journal of Modern Nursing
关键词
肝硬化
酸奶
益生菌
慢性肝病问卷
Liver cirrhosis
Yogurt
Probiotic
Chronic liver disease questionnaire（CLDQ）
