摘要
目的 研究冠心病患者血清超敏C-反应蛋白（Hs-CRP）、超敏肌钙蛋白T（Hs-cTnT）的测定及分析两者与左心室功能的关系。方法 100例冠心病患者（观察组）和50例（对照组）年龄相当的健康受试者纳入该研究,分别测定左心室功能以及血清Hs-CRP和Hs-cTnT水平。结果 与对照组相比,观察组Hs-CRF和Hs-cTnT水平明显升高（t=11.745、7.803,均P＜0.01）,观察组左室舒张末内径（LVEDD）水平显著升高（t=4.984,P＜0.01）,而左室射血分数（LVEF）和左室短轴缩短率（FS）均显著降低（t=5.021、4.672,均P＜0.01）。观察组不同YNHA分级,其Hs-CRF、Hs-cTnT水平、LVEF、LVEDD及FS等差异均有统计学意义（F=89.463、143.463、24.352、30.621、15.724,均P＜0.01）。相关分析结果显示,Hs-CRP、Hs-cTnT水平分别与NYHA分级、LVEDD正相关（r=0.849、0.752、0.807、0.785,均P＜0.05）,Hs-CRP、Hs-cTnT水平分别与LVEF、FS负相关（r=－0.605、－0.754、－0.536、－0.806,均P＜0.05）。结论 冠心病患者血清Hs-CRP和Hs-cTnT水平显著升高,并且与心脏功能显著相关,可作为诊断冠心病心脏功能的指标。
Objective To research the determination of hypersensitivity C-reactive protein（Hs-CRP） and cardiac troponin T（Hs-cTnT） in patients with coronary heart disease,and to analyze the correlation with cardiac function.Methods The function of left ventricle and the serum levels of Hs-CRP and Hs-cTnT in 100 patients with coronary heart disease and 50 healthy subjects were detected.Results The function of left ventricle and the serum levels of Hs-CRP and Hs-cTnT were significantly different in patients with coronary heart disease and healthy subjects（P〈0.01）.The function of left ventricle and the serum levels of Hs-CRP and Hs-cTnT were significantly different in coronary heart disease patients with different New York Heart Association class（P〈0.01）.The serum levels of Hs-CRP and Hs-cTnT were positively correlated with class of New York Heart Association,left ventricular end diastolic diameter,and negatively correlated with left ventricular ejection fraction and fraction shortening（Absolute value of r：0.536～0.849,P〈0.05）.Conclusion The serum levels of Hs-CRP and Hs-cTnT significantly increase in patients with coronary heart disease,which is correlated to function of left ventricle,and it can be used as the indicators of cardiac function in patients with coronary heart disease.
出处
《中国基层医药》
CAS
2013年第12期1814-1816,共3页
Chinese Journal of Primary Medicine and Pharmacy
