摘要
目的 探讨谷氨酰胺对急性肺损伤肺部转归的影响。方法 将70例急性肺损伤患者根据数字表格法随机分为对照组和谷氨酰胺治疗组（Gln组）,每组35例。两组均给予常规治疗和肠外营养支持,Gln组同时给予谷氨酰胺治疗。治疗7 d,比较两组患者机械通气时间、重症监护室停留时间和治疗前后的APACHE II评分、Murray肺损伤评分。结果 两组治疗后APACHE II评分和Murray肺损伤评分较治疗前均明显改善（均P〈0.05）,其中Gln组治疗后APACHE II评分和Murray肺损伤评分分别为（6.54±2.31）分和（0.53±0.42）分,均低于对照组治疗后的（10.43±2.15）分和（1.53±0.62）分（t=3.15、2.17,均P〈0.05）。Gln组机械通气时间和重症监护室停留时间分别为（6.17±4.53）d、（13.41±8.74）d,均少于对照组的（11.57±5.25）d、（21.34±10.27）d（t=2.78、4.62,均P〈0.05）。结论 谷氨酰胺有利于改善急性肺损伤患者的转归,是危重患者肠外营养的有效药物。
Objective To explore the influence of glutamine on the outcome of acute lung injury.Methods According to the digital table,70 patients with acute lung injury were randomly divided into the control group and glutamine treatment group（Gln group）,35 cases in each group. After 7 days treatment,APACHE II score Murray lung injury score,duration of mechanical ventilation and ICU stay time of the two groups were compared.Results After treatment,the APACHE II score and the Murray lung injury score were also improved（all P〈0.05）.The APACHE II score and the Murray lung injury score of the Gln group were （6.54±2.31） points and （0.53±0.42） points,respectively,which were significantly lower than those of the control group[（10.43±2.15） points and （1.53±0.62） points]（t=3.15,2.17,all P〈0.05）.The duration of mechanical ventilation and ICU stay time of the Gln group were （6.17±4.53）d,（13.41±8.74）d,respectively,which were significantly less than those of the control group[（11.57±5.25）d,（21.34±10.27）d]（t=2.78,4.62,all P〈0.05）.Conclusion Glutamine treatment can improve the prognosis of patients with acute lung injury,and it is a parenteral nutrition drug for critically ill patients.
出处
《中国基层医药》
CAS
2013年第11期1636-1638,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
呼吸窘迫综合征
成人
谷氨酰胺
药理学
Respiratory distress sydrome,adult
Glutamine
Pharmacology
