摘要
目的:探讨原发性高血压肾病患者血浆ET-1和血清APN、CysC水平的变化及临床意义。方法:应用放射免疫分析和酶联法对32例原发性高血压肾病患者进行血浆ET-1和血清APN、CysC检测,并同时与35名正常人作比较。结果:原发性高血压肾病患者血浆ET-1和血清APN、CysC水平显著地高于正常人组(P<0.01),而血清APN水平又非常显著地低于正常人组(P<0.01),血浆ET-1水平与CysC水平呈正相关(r=0.6228,P<0.01),与APN水平呈显著负相关(r=-0.4012,P<0.01)。结论:检测原发性高血压肾病患者血浆ET-1和血清CysC、APN水平的变化,两者均具较高检测率。因此,有助于对疾病进程的评估,包括发病机制、预防和指导用药方针。
Objective To explore the clinical significance of changes on plasma ET-1 and serum CysC, APN levels in patients with essential hypertension complicated with nephropathy. Methods Plasma ET-1（with RIA）, serum CysC, APN（with ELISA） levels were measured in 32 patients with essential hypertension complicated with nephropathy prominently and compared to 35 normal controis simultaneously. Results Plasma ET-1 and serum CysC levels were significantly higher in the patients than those in controls（P 〈 0.01 ）. while the serum APN level was remarkably lower（ P 〈0.01 ）. Plasma ET-1 level was positively correlated with CysC（ r = 0.6228, P 〈 0.01 ）. Plasma ET-1 level was significantly negatively correlated with APN （ r = - 0.4012, P 〈 0.001 ）. Conclusion Both the changes of plasma ET-1 and serum GysC, APN levels have high detection rote, thus might be helpful to the assessment of the diseases process, such as pathogenesis, prevention and guidlines foropharmacological therapy.
出处
《放射免疫学杂志》
CAS
2013年第3期275-277,共3页
Journal of Radioimmanology
关键词
原发性高血压肾病
内皮素-1
胱抑素C
脂联素
primary hypertension nephropathy, endothelin-1 （ET-1）, cystatin C （ CysC）, adiponectin（APN）
