摘要
目的探讨在健康人服用复方尼群地平片时,饮食对其药代动力学的影响。方法将8例健康志愿者分成2组(每组4例),均单次服用复方尼群地平片,剂量相同。A组受试者食物与药物同时服用,B组受试者先服药后进食。14 d后,2组交叉。服用复方尼群地平的当天采血,并用高效液相色谱法分别测定血浆中尼群地平和阿替洛尔浓度。结果 2种服药方案尼群地平的血药浓度参数无显著性差异,而受试者进食同时服用复方尼群地平片后阿替洛尔的AUC及药物峰浓度降低而清除半衰期不受显著影响。结论饮食可能减少复方尼群地平中阿替洛尔的吸收或降低其生物利用度,因此建议复方尼群地平片应空腹服用。
Objective It is to approach the influence of diet on pharmacokinetics of compound nitrendipine tablets. Methods Eight cases of health volunteers were divided into two groups （ n = 4）, they were given the same dosage of compound nitrendipine tablets once. Volunteers took the pills with food in group A, and took the pills before eating in group B. After fourteen days, volunteers of group B took the pills with food, and group A took the pills before eating. All the volunteers were drawn blood from the vein, which were used to detect the concentration of nitrendipine and atenolol. Results There was no significant difference in parameters of nitrendipine concentration between two groups. The AUC and peak value of atenolol con- centration was decreased but the half life period was unaffected in those of taking pills and food together. Conclusion Food may reduce the absorption or bioavailability of nitrendipine, so compound nitrendipine tablets should be taken fasting.
出处
《现代中西医结合杂志》
CAS
2013年第17期1833-1835,1839,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
