摘要
新生儿坏死性小肠结肠炎（neonatal necrotizing enterocolitis，NEC）是新生儿常见的胃肠道疾病，近年来随着新生儿重症监护室的建立、围产医学和儿科学的全面发展，早产儿特别是极低出生体重儿存活率明显提高，该病发病率呈逐年上升。目前普遍认为NEC为多高危因素如早产、低体重、感染、窒息、不合理用药等作用于不成熟的肠道引发，但以上因素诱发NEC的机制目前尚未阐述清楚。该文对这些高危因素可能诱发NEC的机制进行阐述。
Neonatal necrotizing enterocolitis is a common gastrointestinal disease in neonate, Recenuy, with the establishment of the NICU and the all-round development of perinatal medicine and pediatrics,survival rate of premature especially very low birth weight neonates have obviously increased and the incidence of the dis-ease is rising year by year. It is generally considered that multiple risk factors such as premature birth, low birth weight, infections, asphyxia, irrational use of drugs and so on, acting on the immature intestine ,but the pathogen-esis is still unknown. Therefore,it is significant to clearify the pathogenesis of the risk factors of NEC for stud-ying the pathogenesis of the disease and providing prevention and control strategy.
出处
《国际儿科学杂志》
2013年第3期230-233,共4页
International Journal of Pediatrics
基金
国家自然科学基金资助项目（81170603）
