摘要
目的随着恶性肿瘤化疗等免疫抑制药物的应用,临床中发现念珠菌的发病率呈上升趋势,非白色念珠菌与白色念珠菌的比例有所增加,这与抗真菌药物的选择性压力有关。临床常见致病念珠菌中以白色念珠菌与热带念珠菌毒力最强,念珠菌的致病力不是由单一因素决定的,而是由一组因素决定,包括二相性转换、疏水性、粘附性、磷脂酶活性、天冬氨酸蛋白酶活性、溶血性等。念珠菌的毒力因子和致病机制非常复杂,对这些致病菌的致病性的了解,必将有助于对念珠菌感染的预防和治疗。
Objective With the application of chemotherapy for malignant tumors and immunosuppressive drugs,we found that more patients were experiencing Candida infection.The selective pressure of the antifungal drugs resulted in the increasing proportion of non Candida albicans and Candida albicans.Candida albicans and Candida tropicalis have the strongest virulence in clinically common pathogenic Candida.The pathogenicity of Candida is not decided by a single factor,but by a group of factors,including the dimorphic transition,hydrophobicity,adhesion,phospholipase activity,aspartic proteinase activity,and hemolysis,etc..Candida albicans virulence factors and pathogenic mechanism are very complicated.The understanding of the pathogen＇s pathogenicity will contribute to the prevention and treatment of Candida infection.
出处
《中国微生态学杂志》
CAS
CSCD
2013年第5期604-608,共5页
Chinese Journal of Microecology
基金
北京市自然科学基金资助(7122133)
关键词
念珠菌
致病力
二相性转换
疏水性
粘附性
Candida
Pathogenicity
Dimorphic transition
Hydrophobicity
Adhesion
