摘要
目的探讨脂氧素A4受体(ALX)在大肠癌组织中的表达及其与各临床病理因素间的关系。方法应用免疫组织化学方法(SABC法)检测正常大肠组织、大肠腺瘤组织及大肠癌组织中脂氧素A4受体的表达。结果 ALX在正常大肠组织、大肠腺瘤组织及大肠癌组织中表达逐渐降低,3组间比较差异有统计学意义(P<0.05);ALX在不同分化程度的大肠癌组织中表达依次降低,但无显著性差异(P>0.05);ALX在不同Dukes分期的大肠癌组织中差异无统计学意义(P>0.05)。结论 ALX在大肠癌的发生发展中起重要作用,具有一定的疾病预防、临床诊断的指导意义。
Objective To investigate the expression of lipoxin A4 receptor （ALX） in the colorectal cancer and its correlation with clinical pathologic factors. Methods The expression of lipoxin A4 receptor was detected by immunohis- tochemical staining in normal coloretal tissues, colorectal adenoma tissues and coloretal cancer tissues. Results The ex- pression of ALX in normal coloretal tissues, colorectal adenoma tissues and coloretal cancer tissues reduced gradually, the difference among three groups was statistically significant （P 〈 0.05）. The expression of ALX in different differenti- ation degree of colorectal cancer tissues reduced gradually, but there was no significant difference （P 〉 0.05）. There was no significant difference of ALX expression in different Dukes stage of eolorectal cancer tissue （P 〉 0.05 ）. Conclu- sion The occurrence of ALX plays an important role in the development in colorectal cancer.
出处
《胃肠病学和肝病学杂志》
CAS
2013年第5期425-427,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
大肠癌
脂氧素A4受体
免疫组化
Coloretal cancer
Lipoxin A4 receptor
Immunohistochemistry
