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噻吩吡啶类抗血栓药物的结构改进专利分析和发展趋势 被引量:4

Analysis and Development of Patents in Structure Modification of an Antiplatelet Agent of Thienopyridine
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摘要 心血管疾病已严重危害人类健康,血小板抑制剂可有效改善和预防心血管疾病。噻吩吡啶类药物具有较好的抗血小板凝集的效果,并降低副作用,因此噻吩吡啶类药物抑制剂的研究已成为心血管疾病治疗的热点。本文分析了专利中噻吩吡啶类抗血栓药物的结构改进方向,希望为国内的制药行业在研发方向以及立项过程提供帮助。 At present, cardiovascular disease has seriously jeopardized the health of mankind, and platelet inhibitor can effectively improve and prevent this disease. An antiplatelet agent of thienopyridine have effective and rapid inhibitory effects on platelet aggregation with less side effect, therefore, the study of an antiplatelet agent of thienopyridine has become the focus of the treatment of cardiovascular disease. In this article, we review and analyze the structure modification of thienopyridine in the patents, for the sake of offering a little help to the domestic pharmaceutical industry on patent application or project establishment.
出处 《食品与药品》 CAS 2013年第3期180-183,共4页 Food and Drug
关键词 噻吩吡啶 噻氯匹啶 氯吡格雷 普拉格雷 血小板抑制剂 thienopyridine ticlopidine clopidogrel prasugrel antiplatelet agent
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  • 1[1]Brandt JT,Farid NA,Jakubowski JA,et al.Treating cardiovascular diseases with a compound of formula(I)(CS 747-Prasugrel;RN 150322-43-4)[P].World(PTC)Patent:WO098713,2004-11-18. 被引量:1
  • 2[2]Wiviott SD,Antman EM,Gibson CM,et al.Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes:design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrd Thrombolysis In Myocardial Infarction 38(TRITON-TIMI 38)[J].Am Heart J,2006,152(4):627-635. 被引量:1
  • 3[5]Wiviott SD,Braunwald E,Mecabe CH,et al.Prasugrel versus clopidogrel in patients with acute coronary syndromes[J].N Engl J Med,2007,357(20):2001 -2015. 被引量:1
  • 4[6]Serahruany VL,Midei MG,Meilman H,et al.Platelet inhibition with prasugrel (CS-747) compared with clopidogrel in patients undergoing coronary stenting:the subset from the JUMBO study[J].Postgrad Med J,2006,82(968):404-410. 被引量:1
  • 5[7]Sugidachl A,Asai F,Ogawa T,et al.The in vivo pharmacologiccal profile of CS-747,a novel antiplatelet agent with platelet ADP receptor antagonist properties[J].Br J Pharmacol,2000,129(7):1439-1446. 被引量:1
  • 6[8]Brandt JT,Payne CD,Wiviott SD,et al.A comparison of prasugrel and clopidogrel loading doses on platelet function:magnitude of platelet inhibition is related to active metabolite formation[J].Am Heart J,2007,153(i):66.e9 -e16. 被引量:1
  • 7[9]Wallentin L,Varenhorst C,James S,et al.Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease[J].Eur Heart J,2007,29(1):21 -30. 被引量:1
  • 8[10]Wiviott SD,Antman EM,Winters KJ,et al.Randomized comparison of prasugrel (CS-747,LY640315),a novel thienopyridine P2Y12 antagonist,with clopidogrel in pereutaneous coronary intervention[J].Circulation,2005,111 (25):3366-3373. 被引量:1
  • 9[11]Rehmel JL,Eckstein JA,Farid NA,et al.Interactions of two major metabolites of prasugrel,a thienopyridine antiplatelet agent,with the cytochromes P450[J].Drug Metab Dispos,2006,34(4):600 -607. 被引量:1
  • 10[12]Brandt JT,Farid NA,Jakubowski JA,et al.Dosage regimen for prasugrel[P].World(PTC) Patent:WO-138317,2006-12-28. 被引量:1

共引文献29

同被引文献49

  • 1张丽华,杜雪,何培源,蒋立新.P2Y_(12)受体拮抗剂最新研究进展[J].中华临床医师杂志(电子版),2012,6(19):6001-6003. 被引量:3
  • 2胡先明,白丽霞,王丽燕,郭晓燕,李祥生,梁渊,卢祖洵.亚健康与心脑血管疾病[J].中西医结合心脑血管病杂志,2007,5(1):65-66. 被引量:9
  • 3Najafi M,Sheikhvatan M.Gender differences in coronary artery disease:correlational study on dietary pattern and known cardiovascularrisk factors[J].Int Cardiovasc Res J,2013,7(4):124-129. 被引量:1
  • 4Takeshita J,Mohler ER,Krishnamoorthy P,et al.Endothelial cell-,platelet-,and monocyte/m acrophage-derived microparticles are elevated in psoriasis beyond cardiometabolic risk factors[J].J Am Heart Assoc,2014,3(1):507. 被引量:1
  • 5Zahno A,Bouitbir J,Maseneni S,et al.Hepatocellular toxicity of clopidogrel:Mechanisms and risk factors[J].Free Radic Biol Med,2013,65(7):208-216. 被引量:1
  • 6Han YM,Hahm KB,Park JM,et al.Paradoxically augmented antitumorigenic action of proton pump inhibitor and gastrin in APCMin/+intestinal polyposis model[J].Neoplasia,2014,16(1):73-83. 被引量:1
  • 7Lima JJ,Franciosi JP.Pharmacogenomic testing:the case for CYP2C19 proton pump inhibitor gene-drug pairs[J].Pharmacogenomics,2014,67(8):198-204. 被引量:1
  • 8Bytzer P,Jones R,Vakil N,et al.Limited ability of the protonpump inhibitor test to identify patients with gastroesophageal reflux disease[J].Clin Gastroenterol Hepatol,2012,10(12):1360-1366. 被引量:1
  • 9Hokimoto S,Mizobe M,Akasaka T,et al.Impact of CYP2C19 polymorphism and proton pump inhibitors on platelet reactivity to clopidogrel and clinical outcomes following stent implantation[J].Thromb Res,2014,133(4):599-605. 被引量:1
  • 10Sibbing D,Morath T,Stegherr J,et al.Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel[J].Thromb Haemos,2009,101(4):714-719. 被引量:1

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