摘要
以羟丙基甲基纤维素为凝胶骨架材料 ,以淀粉 糊精混合物及乳糖为填充剂 ,采用湿法制粒压片 ,制备了盐酸地尔硫缓释片 ,并对其释放度进行了测定 .所制备的缓释片在释放 90 %之前的释放符合Higuchi方程 .片剂中羟丙基甲基纤维素的含量及稀释剂的种类与含量对药物的释放速度有较大影响 ,而压片力对药物的释放速度无明显影响 .
This article indroduces the preparation method of diltiazem hydrochloride sustained release tablets. Hydroxypropylmethyl cellulose (HPMC) was used as hydrophilic matrix. Starch dextrin mixture and lactose were used as additives respectively. The tablets were prepared by the wetting granule method, and its release rates were detected. The drug release from the tablets fitted to the Higuchi equation. The content of HPMC and additives in the tablets and different additives had significant influence on release rates, but the compressing force had little influence on the release rate from the tablets. The drug release rate could be changed as the amount of HPMC and the variety of additives changed.
出处
《沈阳药科大学学报》
CAS
CSCD
2000年第5期313-315,共3页
Journal of Shenyang Pharmaceutical University
