摘要
目的:观察利拉鲁肽对糖耐量异常OLETF大鼠糖脂代谢及骨代谢的影响。方法 :32只12周龄糖耐量异常的OLETF大鼠随机分为生理盐水组和不同剂量利拉鲁肽干预组(50、100、200μg/kg),8只同种系LETO大鼠作为正常对照组。实验结束时,所有大鼠均检测糖脂及骨代谢指标。结果:生理盐水组OLETF大鼠与LETO组相比,血糖、总胆固醇、甘油三酯升高(P<0.05),骨钙素及降钙素差异无显著性;利拉鲁肽干预后,血糖、总胆固醇、甘油三酯降低,骨钙素、降钙素升高。结论:利拉鲁肽能够改善自发糖耐量异常动物模型糖脂代谢及骨代谢状况,促进骨形成,抑制骨吸收,延缓或预防高糖所致的骨质恶化。
Objective To investigate the effects of liraglutide on glucose,lipid and bone metabolism in OLETF rats with impaired glucose tolerance（IGT）.Methods 32 twelve-week-old OLETF rats were randomized into 4 groups and received normal saline（NS group） or 50,100,or 200 μg / kg of liraglutide for 12 weeks,respectively.8 LETO rats served as controls and received normal saline（LETO group）.After the treatment,parameters about glucose,lipid and bone metabolism were examined.Results Compared with LETO group,fasting blood glucose（FBG）,total cholesterol（TC）,triglyceride（TG） were increased in NS group（P 0.05）,while osteocalcin and calcitonin had no significant difference.After administered by liraglutide,FBG,TC,and TG of rats were decreased,while osteocalcin and calcitonin were increased.Conclusions Liraglutide can improve glucose,lipid and bone metabolism in OLETF rats.
出处
《实用医学杂志》
CAS
北大核心
2013年第10期1573-1575,共3页
The Journal of Practical Medicine
基金
中华国际医学交流基金会资助项目(编号:2100325)
国家自然科学基金资助项目(编号:81270966)
广东省自然科学基金资助项目(编号:S2012010009494)
关键词
利拉鲁肽
糖耐量异常
OLETF大鼠
骨形成
骨吸收
Liraglutide
Impaired glucose tolerance
OLETF rats
Bone formation
Bone resorption
