摘要
目的 探讨沐舒坦（盐酸氨溴素）对气管插管全麻＞3 h的上腹部手术老年患者呼吸道的保护作用. 方法 88例老年上腹部手术患者随机分为2组,剔除气管导管留置≤3h的病例,治疗组（41例）应用抗生素＋沐舒坦（90 mg,静脉滴注,2次/d,连续7 d）；对照组（39例）应用相同抗生素,不用沐舒坦.比较两组手术前后肺功能,血气分析以及肺部情况的变化. 结果 术后第3天开始,治疗组血气分析与同期对照组数据相比差异有统计学意义（P＜0.05）,术后第5天起,两组1s用力呼气容积和1 s用力呼气容积占用力肺活量比值差异有统计学意义（P＜0.05）,肺活量手术前后未见明显变化.治疗组肺部感染2例（4.9％）,肺不张0例；对照组肺部感染者9例（23.1％）,肺不张4例（10.3％）,差异有统计学意义（P＜0.05）. 结论 沐舒坦在老年患者接受上腹部手术后对呼吸系统有很好的保护作用,与抗生素合用可达到协同增效的目的.
Objective To investigate the clinical effects of mucosolvan on the respiratory tract in elderly patients with long-time tracheal intubation for upper abdominal operation.Methods A total of 88 elderly patients to receive upper abdominal surgery were randomly divided into 2 groups：the treatment group （n=41,treated with antibiotics and mucosolvan 90 mg,iv,bid,for 7 consecutive days） and the control group （n=39,with the same antibiotics but without mucosolvan）.Patients indwelling endotracheal tube≤3 hours were excluded.Lung function [forced vital capacity （FVC）,forced expiratory volume in 1 second （FEV1）,FEV1/FVC ratios （FEV1%）],blood gas analysis （pH,PaCO2,PaO2） and lung condition changes were compared between the two groups before and after surgery.Results There was a significant difference in blood gas analysis between the two groups 3 days after surgery （P〈0.05）.There were differences in FEV1 and FEV1% between the two groups 5 days after surgery （P〈0.05）,Conclusions Mucosolvan has a better protective effect on the respiratory tract in elderly patients undergoing upper abdominal surgery and the synergies can be achieved in combination with antibiotics.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2013年第5期516-517,共2页
Chinese Journal of Geriatrics
关键词
外科手术
呼吸道感染
氨溴素
Surgical procedures l Respiratory tract infection
Ambroxol
