摘要
散发型克雅病患者共计5例,临床主要表现为快速进展性痴呆,发病时间1～4个月。其中2例脑电图呈现特征性周期性同步放电,4例脑脊液14-3-3蛋白检测阳性。MRI扩散加权成像均显示皮质或基底节对称性或非对称性"彩带"样高信号,提示扩散加权成像对克雅病的诊断敏感且具有特异性,可作为临床首选检查方法。
Five patients with sporadic Creutzfeldt- Jakob disease （sCJD） presented rapidly progressive dementia which were snbaeute onset from l to 4 months. Among these cases, periodic synchronous discharge （PSD） of electroencephalography （EEG） was seen in 2 patients. Besides, 4 patients obtained positive results in cerebrospinal fluid （CSF） analysis for 14- 3- 3 protein. The cranial MRI examination showed symmetrical or asymmetrical colored-ribbon-shaped high signals in cerebral cortex or basal ganglia by diffusion weighted imaging （DWI）, suggesting that DWI had high sensitivity and specificity for the diagnosis of sCJD as a preferred method in the clinical examination of sCJD.
出处
《中国现代神经疾病杂志》
CAS
2013年第4期334-337,共4页
Chinese Journal of Contemporary Neurology and Neurosurgery
关键词
克-亚综合征
磁共振成像
弥散
临床表现
Creutzfeldt-Jakob syndrome
Diffusion magnetic resonance imaging
