摘要
目的观察腹腔镜手术与注射用醋酸曲普瑞林联合治疗子宫内膜异位症的临床疗效。方法 120例子宫内膜异位症腹腔镜术后患者随机分为2组:试验组组(腹腔镜手术联合注射用醋酸曲普瑞林,40例)和对照组(腹腔镜手术联合孕三烯酮,80例)。试验组肌肉注射醋酸曲普瑞林3.75 mg,每28 d注射1次,连用6个月;对照组于手术后月经来潮第1 d,开始口服孕三烯酮2.5 mg,每周2次,连续3～6个月,比较2组疗效及不良反应。结果试验组显效率高于对照组,而复发率低于对照组,但差异均无统计学意义(P>0.05);2组排卵时间的恢复分别为(18.32±6.86),(21.81±6.07)d,试验组明显少于对照组(P<0.05)。痤疮、体重增加、胃肠道反应等不良反应,试验组明显高于对照组(P<0.05)。结论腹腔镜术后联合注射用醋酸曲普瑞林治疗子宫内膜异位症疗效确切。
Objective To investigate the effect of triptorelin acetate for injection after operation with laparoscopy in the treatment of endometriosis. Methods One hundreds and twenty patients with endometriosis were treated in this hospital from January, 2009 to January 2012. All these patients were randomly divided into two groups： trial group （with triptorelin acetate for injection , n = 40） and control group （with gestri- none, n = 80）. The trial group was given intramuscular injection triptore- lin acetate for injection 3.75 mg, 1 time per 28 days, the time of dura- tion is 6 months, the gestrinone group, oral gestrinone 2. 5 mg, 2 times per week, first day after operation of menstrual cramps, for 3 -6 months. The curative effect and adverse reaction were compared in two groups. Results The clinical effect of triptorelin acetate for injection group is higher than gestrinone group. The relapse rate is lower than the gestrinone group. But the differences were not significant （P 〉 0. 05 ）. At the time of ovulation recovery time, were significantly less than that in the gestrinone group （ P 〈 0.05 ）. The acne, weight increase, gastroin- testinal reactions and other adverse reactions was significantly higher than the gestrinone group （ P 〈 0. 05 ）. Conclusion Laparoscopic postoperative joint triptorelin acetate for injection in treatment of endometriosis clinical curative effect, which should be according to the patient＇s general condition selection of appropriate drugs.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2013年第5期339-341,共3页
The Chinese Journal of Clinical Pharmacology
