摘要
目的研究静脉应用重组人脑利钠肽（rhBNP）对经静脉溶栓治疗急性心肌梗死合并心力衰竭患者左心功能和左室重构的影响。方法将78例首发急性前壁sT段抬高心肌梗死合并心力衰竭患者分为rhBNP治疗组（36例）和对照组（42例）。比较两组患者治疗前及治疗后24、48h血浆NT—proBNP水平，并观察两组患者出院时及出院后1个月的心功能和左室重构变化。结果治疗48h时，与对照组比较，rhBNP组血浆rhBNP水平下降更明显（P〈0．05）；两组患者出院时左心室舒张末期容积（LVEDV）比较差异无统计学意义（P〉0．05），而rhBNP组LVEF值较对照组明显升高（P〈0．05）；出院后1个月时，rhBNP组LVEF值较对照组仍明显升高（P〈0．05），而rhBNP组LVEDV及ALVEDV％较对照组明显降低（P〈0．05）。结论rhBNP能有效改善急性心肌梗死后心力衰竭患者心功能，延缓左室重构。
Objective To evaluate the influence of recombinant human brain natriuretic peptide （rhBNP） on left ventricular function and left ventricular remodeling （LVR） in the patients with anterior wall acute myocardial infarction （AMI） and acute heart failure after thrombolysis therapy. Methods 78 patients with acute anterior myocardial infarction and heart failure for the first time were divided into rhBNP group （36 cases） and the control group （42 cases）. The NT - proBNP level were compared between the two groups at baseline and 24,48 h after baseline. The echocardiogram was performed at discharge and 1 month after discharge in order to observe the improvement of cardiac function and left ventricular remodeling. Results Compared with control group, rhBNP group showed the obvious decrease of plasma NT - proBNP at 48 h after treatment （ P 〈 0.05 ）. At discharge, the left ventricular end - diastolic volume （ LVEDV ） had no significant difference between two groups （ P 〉 0.05 ）, while the left ventricular ejection fraction （LVEF） showed apparent increase in rhBNP group（P 〈 0.05 ）. At 1 month after discharge, the LVEF was still higher in rhBNP group than in control group（ P 〈 0.05 ）, while the LVEDV and ALVEDV% showed obvious decrease in rhBNP group （ P 〈 0.05 ）. Conclusion rhBNP can improve the left ventricular function and inhibit the remodeling of left ventricular.
出处
《中国急救医学》
CAS
CSCD
北大核心
2013年第5期436-439,共4页
Chinese Journal of Critical Care Medicine
