摘要
目的:通过联合检测血清中EB病毒壳抗原免疫球蛋白A抗体(VCA-IgA),癌胚抗原(CEA)和铁蛋白(SF),探讨该联合检测在鼻咽癌(NPC)临床诊断中的价值。方法:利用免疫酶法和化学发光免疫分析技术,分别检测临床确诊的102例NPC患者和54例正常人血清中VCA-IgA和CEA,SF的表达水平。结果:NPC患者中VCA-IgA、CEA和SF单独检测敏感性分别为81.3%、68.6%和48%,正常组中敏感性分别为1.8%、3.7%和1.8%。两组中VCA-IgA、CEA和SF联合检测敏感性差异显著(P<0.01),分别为93.8%和5.5%。结论:联合检测血清中VCA-IgA,CEA和SF的表达水平,在临床诊断NPC中具有很好的特异性,有一定的推广价值。
Objective： Through the combined detection of EB virus capsid antigen immunoglobulin A antibody（VCA-IgA）,carcinoembryonic antigen（CEA） and ferritin（SF） in serum of nasopharyngeal carcinoma（NPC） patients,to explore the joint detection value in the clinical diagnosis of NPC.Methods： We selected 102 patients with nasopharyngeal carcinoma after the radical surgery in our unit as NPC group,and 54 healthy subjects as normal group.Used immune enzymatic and chemical luminescence immunoassay to detect the expression levels of VCA-IgA,CEA and SF in their serum.Results： VCA-IgA,CEA and SF alone detection sensitivity is 81.3%,68.6% and 48% respectively in NPC group,and the normal group sensitivity were 1.8%,3.7% and 1.8%.There are significant differences between the NPC group and normal group（P0.01）,detection sensitivity is 93.8% and 5.5% respectively.Conclusion： The expression levels detection of VCA-IgA antibody joint with CEA and SF in the serum of NPC patients is a good way of NPC clinical diagnosis,and with good specificity,and this method is worthy of promoting.
出处
《现代生物医学进展》
CAS
2013年第13期2514-2516,2520,共4页
Progress in Modern Biomedicine
