摘要
目的:探讨血清生物标记物与膝关节单纯性滑膜炎的严重程度及预后的相关性。方法:选取我科2011年6月至2012年9月收治的64例膝关节单纯性滑膜炎患者为滑膜炎组,60例同期健康志愿者作为对照组。采用酶联免疫吸附实验(ELISA)法检测其血清中透明质酸、软骨寡聚蛋白、血管内皮生长因子的含量。滑膜炎评分采用术中关节镜下Ayral评分,分别在术前及术后三周对所有患者进行膝关节lysholm评分及视觉模拟评分(VAS)。结果:滑膜炎组血清透明质酸、血管内皮生长因子的含量均显著高于对照组(P<0.05),但两组软骨寡聚蛋白含量比较无统计学差异(P>0.05)。Ayral滑膜炎评分≥60分组血清HA、VEGF含量显著高于Ayral滑膜炎评分<60分组(P<0.05)。术后3周,滑膜炎患者的lysholm评分及VAS评分均较术前的明显改善(P<0.05)。HA含量的高低与lysholm评分差值具有相关性(P<0.05,r=0.743)。VEGF含量高低与lysholm评分差值呈负相关(P<0.05,r=-0.494)。结论:滑膜炎患者血清HA、VEGF的含量与滑膜炎的严重程度和预后均有关,对早期诊断膝关节单纯性滑膜炎的病情严重程度有一定的参考价值,可作为临床检查和影像学诊断的有益补充。
Objective： To investigate the correlation of content of the serum biomarkers with knee joint synovitis. Methods： 64 patients with traumatic knee joint synovitis admitted in our department from June 2011 to September 2012 were randomly selected as synovitis group, 60 healthy people were randomly collected as control group. The enzyme-linked irnmunosorbent experiment （ELISA） method was used to detect the content ofhyaluronic acid, cartilage oligomeric protein, cascular endothelial growth factor in joint fluid as well as in the serum. The intraoperative arthroscopic Ayral score was used to estimate the synovitis score. Lysholm knee score and visual analogue scale （vas） were used to score the synovitis before the operation and three weeks after the operation respectively. Results： The serum contents of hyaluronic acid and cascular endothelial growth factor in the synovitis group were Significantly higher than those in the control group （P〈0.05）, while no statistical difference was found in the content of cartilage oligomeric protein between two groups （P〉0. 05）. The serum HA, VEGF content of the synovitis group with the Ayral synovitis score ≥60 were much higher than the same group with the Ayral synovitis score 〈 60 （P〈0.05）. The postoperative lysholm score and VAS score were obviously improved （P〈0.05）. There was a significant correlation between the HA content and the VAS score difference （P〈0.05, r=-0.743）. VEGF content had a negative correlation with lysholm score （P〈0.05, r=-0.494）. Conclusion： The serum content of HA, VEGF were related to the severity and prognosis of synovitis, which had value in the diagnosis and evaluation of the prognosis of synovitis and could be used to forecast the prognosis of the disease.
出处
《现代生物医学进展》
CAS
2013年第12期2289-2292,共4页
Progress in Modern Biomedicine
关键词
单纯性滑膜炎
透明质酸
血管内皮生长因子
软骨寡聚蛋白
膝关节评分
Knee joint synovitis
Hyaluronic acid
Vascular endothelial growth factor
Cartilage oligomeric matrix protein
Lysholm knee score scale
