摘要
【目的】探讨高血压脑出血迟发型脑水肿与高同型半胱氨酸血症的关系。【方法】对本院收治的62例高血压性脑出血患者的I临床资料进行回顾性分析，62例中发生迟发型脑水肿的患者26倒作为A组，36例无迟发型脑水肿者作为B组，选择同期体检的非高血压脑出血人群30例作为对照组（C组）。所有患者入院当天、治疗ds、治疗后d10测定血浆同型半胱氨酸（Hcy）水平，定期行头颅CT检查观察脑水肿情况。【结果】入院当天A组、B组患者血浆Hcy水平明显高于C组，且差异有显著性（P〈0．05）；入院后A、B两组患者Hcy含量均有所升高，但与入院当天相比差异均无显著性。治疗10d后A组血浆Hcy水平明显高于入院时水平，B组则较入院时显著降低（P〈0．05）。【结论】脑出血后迟发型脑水肿与患者血浆Hey水平有关，动态观察血浆Hcy对脑出血的诊断和治疗有积极的意义。
[Objective]To observe the relationship between hyperhomocysteinemia and delayed cerebral e- dema of cerebral hemorrhage. [Methods] Clinical data of 62 patients with hypertensive intracerebral hemor- rhage in our hospital were analyzed retrospectively. In all patients, 26 patients with delayed cerebral edema were selected as group A and 36 patients without delayed cerebral edema were selected as group B. Concurrent 30 non-hypertensive cerebral hemorrhage subjects were chosen as the control group. Plasma homocysteine （Hcy） level of all patients was measured on admission, 3d and 10d after treatment. Head CT was performed periodically to observe cerebral edema. [Results] Plasma Hcy in group A and group B on admission were obvi- ously higher than those in control group, and there was significant difference（ P d0.05）. Plasma Hcy after admission of patients in two groups increased, but there was no significant difference between on admission and after admission. Plasma Hcy in group 10d after treatment was obviously higher than that on admission. Com- pared with on admission, plasma Hcy in group B decreased significantly（ P d0.05）. [Conclusion] Delayed cerebral edema of cerebral hemorrhage is associated with plasma Hcy. Dynamic observation of plasma Hcy is of positive significance for the diagnosis and treatment of cerebral hemorrhage.
出处
《医学临床研究》
CAS
2013年第4期677-678,682,共3页
Journal of Clinical Research
