摘要
目的 探讨重庆地区人群血管紧张素转换酶基因 (ACE)插入 /缺失 (I/ D)多态性与原发性高血压及药物治疗的关系。方法 用多聚酶链反应直接扩增 ACE基因第 16内含子 ,对 114名正常人和 75例原发性高血压患者进行了分析 ,同时对 49例原发性高血压患者用血管紧张素转换酶抑制剂 (ACEI,依拉普利 )和钙通道阻滞剂 (CCB,菲洛地平 )进行自身交叉治疗 ,并比较降压效果。结果 原发性高血压患者ACE基因的 DD型频率和 D等位基因频率明显高于正常人 (χ2 =13.75 ,P<0 .0 0 5 ;χ2 =14.3,P<0 .0 0 5 )。用 ACEI治疗 DD型高血压患者的降压效果比 CCB明显 ,用 CCB治疗 II型高血压患者的降压效果比ACEI明显。结论 重庆地区原发性高血压患者可能与 ACE基因的缺失 (DD)型有关系。开展对
Objective To measure and discuss the association of the angiotensin converting enzyme (ACE) gene insertion/deletion(I/D) polymorphism with essential hypertension and drug treatment in Chongqing. Methods Polymerase chain reaction(PCR) method was used to amplify the sixteenth intron of the ACE gene for the analysis of 114 healthy controls and 75 patients with essential hypertension. At the same time, 49 patients with essential hypertension were randomly divided into two groups for a placebo controlled crossover comparison of ACEI versus CCB. Results The frequency of homozygous alleles DD and the frequency of deletion alleles were significantly higher in the essential hypertension group than in the healthy controls( P <0.005). The blood pressure decreased more in the DD genotype subjects when treated with the ACEI but decreased less when treated with the CCB (15.91 vs 12.43, P >0.1). The blood pressure decreased more in the II genotype subjects when treated with the CCB but decreased less when treated with the ACEI (16.55 vs 9.6, P <0.05). Conclusion The results indicate that a deletion (DD) polymorphism of the ACE gene is associated with essential hypertension in Chongqing. Detection of the ACE genotype in clinics is helpful to the selection of antihypertensive drugs.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2000年第5期340-342,共3页
Chinese Journal of Medical Genetics
关键词
ACE
基因多态性
原发性高血压
药物疗法
angiotensin converting enzyme
gene polymorphism
essential hypertension
response to treatment
