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目标导向液体治疗对脑膜瘤切除术患者心指数及术后康复的影响 被引量:11

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摘要 目的:比较目标导向液体治疗与常规输液方法对脑膜瘤切除术患者围术期心指数(cardiac index,CI)及术后早期康复的影响。方法:择期行仰卧位脑膜瘤切除术患者28例,随机分为两组:目标导向液体治疗组(G组)15例,常规输液组(C组)13例。两组均以维持正常的平均动脉压、红细胞压积与血红蛋白为基础实施液体治疗。C组补液量为生理需要量(4-2-1法则)+额外补充量(4mL/kg)。G组以胸腔内血容积指数(intrathoracic blood volume index,ITBI)在800~1000mL/m2范围内为导向目标:ITBI低于下限者以6%羟乙基淀粉130/0.4(5mL/kg)扩容;ITBI高于上限者进行利尿处理。观测不同时点两组患者的CI及术后康复指标。结果:(1)两组患者CI在不同时点间差异有统计学意义(P<0.05);G组CI值明显高于C组,且呈上升趋势(P<0.05)。(2)两组患者的监护病房停留时间、术后住院天数及术后12h神经功能缺损评分无明显差异(P>0.05);G组术后24h神经功能评分(15.2±4.6)明显低于C组(18.0±2.6)(P<0.05)。(3)两组患者出院时的KPS评分(82.7±6.7)明显低于术前(70.8±6.9)(P<0.01),但两组间比较无明显差异(P>0.05)。结论:脑膜瘤切除术围术期以ITBI指导输液,较常规输液法可明显提高CI,降低患者术后24h神经功能缺损评分,但对早期生存质量无明显影响。
出处 《实用医学杂志》 CAS 北大核心 2013年第9期1458-1460,共3页 The Journal of Practical Medicine
基金 贝朗麻醉科学研究基金资助项目(编号:BB-2011-11)
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