摘要
目的研究2型糖尿病(T2DM)、非酒精性脂肪肝(NAFLD)与脂肪细胞因子的相关性。方法对健康对照组(A组)、NAFLD组(B组)、T2DM组(C组)及T2DM伴NAFLD组(D组)肝功能、血脂、血糖、胰岛素水平、血尿酸、脂联素(ANP)、肿瘤坏死因子(TNF-α)进行测定。结果与A组相比,B、C、D组ANP明显下降(P<0.01),TNF-α明显升高(P<0.01),D组与B、C组相比,ANP下降(P<0.01),TNF-α上升(P<0.01)。结论脂肪细胞因子参与T2DM、NAFLD病理生理过程,恢复脂肪细胞因子的水平是非常有意义的。
Objective To investigate the relationship between T2DM,NAFLD and oxidative stress. Methods Liver function,lipids,blood glucose,insulin,CRP,uric acid,adiponecin and TNF-α were compared between normal control group （group A）, NAFLD group （group B）, T2DM group （group C）,T2DM with NAFLD group （group D）. Results The APN of group B ,group C and group D was significantly lower than group A（P 〈 0.01 ）,TNF-α was significantly higher than group A（P 〈 0.01 ）. The APN of group D was lower than group B and group C（P 〈 0.01 ） ,TNF-α was higher than group B and group C （P 〈 0.01 ）. Conclusion The adipokine is in the process of pathophysiology of T2DM and NAFLD. So, Restore the levels of adipokine is very meaningful.
出处
《中国现代医生》
2013年第14期10-12,共3页
China Modern Doctor
