摘要
目的探讨慢性肺源性心脏病（简称肺心病）患者血清缺氧诱导因子-1α（HIF-1α）和脑利钠肽前体（NT-proBNP）的表达及相关性。方法将90例受试者分为肺心病组、慢性阻塞性肺疾病急性发作期（AECOPD）组和对照组，分别采用双抗体夹心酶联免疫吸附法（ELISA）和化学发光法检测受试者血清HIF-lot和NT-proBNP水平；均在未吸氧情况下用血气分析仪测定动脉血氧分压（PaO2）；肺心病组及AECOPD组均于入院24小时内行超声心动图检查测定肺动脉收缩压（PASP）。结果肺心病组患者血清HIF-1α和NT-proBNP水平均显著高于AECOPD组；AECOPD。组两项指标显著高于对照组。肺心病组患者HIF-1α、NT-proBNP表达与PASP呈正相关（rHIF-1α=0．91，P〈0．01；rNT-proBNP=0．89，P〈0．01），同时HIF-1α与NT-proBNP的表达也呈正相关（r=0．93，P〈0．01）。结论HIF-1α、NT-proBNP的表达水平能反映缺氧性肺动脉高压的严重程度。
Objective To analysis the expression and correlation of hypoxia-inducible factor-let （HIF-1α） and brain natriuretic peptide （NT-proBNP） in the serum of patients with chronic pulmonary heart disease （cor pulmonale）. Methods 90 subjects were divided into 3 groups：pulmonary heart dis- ease group （ n = 30）, chronic obstructive pulmonary disease with acute exacerbation （AECOPD） group （ n = 30） and control group （ n = 30）. All subjects were tested the content of HIF-la and NT-proBNP in ser- um with a double antibody sandwich enzyme-linked immunosorbent assay （ELISA） and chemilumines- cence detection;they were measured the arterial oxygen pressure （PaO2） in the condition without oxygen with a blood gas analyzer; pulmonary heart disease group and AECOPD group were examined the pulmo- nary artery systolic pressure （PASP） with ultrasound echocardiographic determination when they were ad- mitted to hospital within 24 hours. Results The HIF-1α[ （ 1668.12 ± 679.68） ng/L] and NT-proBNP [ （3381.63 ±1437.68） ng/L] in serum of the pulmonary heart dease were significantly higher than the AECOPD group [ respectively, （924.62 ±294. 64） ng/L and （ 655.27 ± 294.64 ） ng/L ] ; AECOPD group was significantly higher than the healthy control group[respectively, （107.60 ±43.71 ） ng/L and （38.03 ±24.81 ） ng/L]. The expression of HIF-lct,NT-proBNP in pulmonary heart disease group and PASP was being related （ rHIF-1α = 0.909, P 〈 0. 01 ; rNT-proBNP= 0. 892, P 〈 0, 01 ）, at the same time the expression of HIF-1α and NT-proBNP was also into being related （r = 0.926, P 〈 0.01 ）. Conclusion The expression levels of HIF-1α and NT-proBNP can reflects the severity of the hypoxic pulmonary artery pressure.
出处
《临床内科杂志》
CAS
2013年第4期241-243,共3页
Journal of Clinical Internal Medicine
