摘要
目的:通过建立猫不同种类的视觉破坏动物模型,探讨图形视觉诱发电位在双眼视觉研究中的作用。方法:健康家猫18只,于4周龄时随机建立正常、形觉剥夺性弱视及光学性斜视模型3组,每组动物各6只,分别在6周龄、10周龄和16周龄时记录各组动物的P波振幅和潜时。结果:随年龄增长,正常组P波潜时缩短,振幅增大,双眼振幅大于单眼反应之和;弱视组在10周龄时右眼振幅低于左眼,差异有统计学意义(P<0.05),潜时无统计学差异;16周龄时右眼(即弱视眼)振幅和潜时均低于左眼,双眼振幅表现为部分总和;光学性斜视组单眼间的P波潜时和振幅相比较以及与正常组相比无明显差异,双眼总和在10周龄和16周龄时小于单眼反应之和。结论:图形视觉诱发电位是评价动物双眼视觉的一种有效手段。
AIM： To evaluate the effect of pattern visual evoked potentioals （P-VEP） in the detection of binocular vision in cat models of visual dysfunction. METHODS： Eighteen 4- week- old healthy domestic cats were included. Twelve of them were used to establish models of monocular deprivation （6 cats） and optical strabismus （6 cats）. The other six cats were used as controls. Their binocular visions were detected by P- VEP when they were 6, 10 and 16 weeks old, and the latency and the amplitude of P waves were recorded. RESULTS： With increasing age, the latency got shortened and the amplitude got enlarged in the control group. The binocular summation was larger than the summation of monocular amplitude. In the monocular deprivation group, the cats had lower amplitude in the right eye than the left eye at 10 weeks old, and the difference was statistically significant （ P〈 0.05） ; There was no statistically significant difference in the latency. When these cats were 16 weeks old, the latency and the amplitude of the right eye （the amblyopic eye） were obviously lower than the left eye, and partial binocular summation was shown. Compared with the control group, the latency and the amplitude of either eye in the optical strabismus group was not significantly different; however, the binocular summations were remarkably lower than either monocular amplitude when the cats were 10 weeks old and 16 weeks old. CONCLUSION： P-VEP is an effective approach for evaluation of the binocular vision in animals.
出处
《国际眼科杂志》
CAS
2013年第5期865-868,共4页
International Eye Science
关键词
图形视觉诱发电位
双眼视觉
弱视
光学性斜视
pattern visual evoked potentioals
binocular vision
amblyopia
optical strabismus
