摘要
目的:分析中医药治疗肝炎肝硬化的配伍组合及其核心药物。方法:以"肝硬化"、"中医"、"证"等为主题词,系统检索中国学术期刊网络出版总库、中文科技期刊全文数据库与中国生物医学文献数据库近20年来所有相关文献,选取其中具有肝炎肝硬化典型病例有效治疗的文献,使用SPSS建立典型病例治疗中所用中医复方的药物数据库,运用SAS对数据进行处理,结合人工降噪后,用复杂网络挖掘中医治疗肝炎肝硬化的两两配伍组合关系及其核心药物。结果:符合纳入分析标准的文献有326篇,涉及病例数共计407例,属于代偿期和失代偿期者分别为80和327例,其中失代偿期的病例均伴有并发症腹水;407例的治疗共涉及药物299味,其中代偿期涉及195味,失代偿期涉及275味;治疗代偿期的常用配伍组合的药物(关联频度≥10%)为白术、茯苓、当归、白芍、鳖甲、丹参等32种药物,核心药物(关联频度≥20%)为白术、丹参、白芍、当归、柴胡、郁金、鳖甲、党参、茯苓、桃仁,治疗失代偿期的常用配伍组合的药物(关联频度≥10%)为茯苓、白术、大腹皮、丹参、泽泻等27种药物,核心药物(关联频度≥20%)为白术、茯苓、大腹皮、丹参、泽泻、黄芪、猪苓、鳖甲、当归、党参。结论:通过复杂网络分析所获得的临床报道所用中医药治疗肝炎肝硬化的用药规律,体现了代偿期的治法以健脾益气、养血疏肝、化瘀软坚为主,失代偿期的治法以健脾益气、行气利水、化瘀软坚为主,可为进一步指导临床用药提供一定的指导。
Objective： To explore the regularity of Chinese medicine application for the treatment of hepatitis cirrhosis based on the analysis of effective case reports with complex networks. Methods： Effective cases of hepatitis cirrhosis were selected according to the inclusion criteria on the basis of review of literatures published between 1991 and 2010 in the databases of Chinese National Knowledge Infrastructure （CNFd）, Chinese Technical Journals （VIP） and Chinese Biology Medicine disc （CBM）. The descriptors used for the retrieval were ＇cirrhosis＇, ＇traditional Chinese medicine＇ and ＇TCM syndrome＇. The herbs used in the treatment of effective cases were collected in the database established with SPSS and the data were analyzed with SAS, meanwhile, data noise was removed with artificial means. The results were presented visually with complex networks. Results： There were 407 effective cases of hepatitis cirrhosis treated with Chinese medicines in the 326 articles, in which 80 cases were diagnosed as compensated cirrhosis and 327 cases as decompensated cirrhosis accompanied with ascites. There were totally 299 herbs used in the treatment of effective cases, in which 195 herbs used for compensated cirrhosis and 275 herbs for decompensated cirrhosis. Taking the common occurrence frequency of equal to or greater than 20% as the inclusion criteria, the main components of Chinese herb compound for compensated hepatitis cirrhosis were Baizhu （rhizome）, Danshen （salvia）, Baishao （radix paeoniae alba）, Danggui （angelica）, Chaihu （radix bupleuri）, Yujin （turmeric）, Biejia （turtle shell）, Dangshen （codonopsis pilosula）, Fuling （poria cocos） and Taoren （peach kernel）, and for decompensated hepatitis cirrhosis were Baizhu （rhizome）, Fuling （poria cocos）, Dafupi （areca peel）, Danshen （salvia）, Zexie （rhizome alismatis）, Huangqi （bupleurum）, Zhuling （agaric）, Biejia （turtle shell）, Danggui （angelica） and Dangshen （codonopsis pi
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2013年第5期1495-1499,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点基础研究发展计划(973计划)资助项目(No.2011CB505105)
北京中医药大学自主选题项目资助(No.2011-JYBZZ-XS083)
北京中医药大学创新团队项目资助(No.2011-CXTD-08)~~
关键词
肝炎肝硬化
中医用药规律
复杂网络
Hepatitis cirrhosis
Regularity of Chinese medicine application
Complex networks
