摘要
目的研究小柴胡汤对饮食诱导的非酒精性脂肪肝大鼠肝功能及血脂的影响。方法健康SPF级Wistar大鼠给予改良的高脂饲料喂养建立非酒精性脂肪肝大鼠模型。60只脂肪肝大鼠随机分为4组:正常对照组、脂肪肝模型组、小柴胡汤[1g/(kg.d)]治疗组、易善复[64mg/(kg.d)]治疗组,每组各15只。分别观察小柴胡汤对非酒精性脂肪肝大鼠体重、肝湿重、血清丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)以及血清和肝组织总胆固醇(TC)、甘油三酯(TG)含量的影响,并与易善复作对照。结果小柴胡汤治疗后,脂肪肝大鼠的体重和肝湿重均明显低于模型组(P<0.05),而且血清ALT、AST、TC、TG水平以及肝脏组织和血清TC、TG含量均明显降低(P<0.05),疗效与易善复组接近。结论小柴胡汤具有治疗非酒精性脂肪肝的作用,其作用机制可能与调节脂质代谢、改善肝功能有关。
Objective To explore the effects of Xiaochaihu Soup on liver function and blood fat in diet- induced rat nonalcoholic hepatitis model. Methods A total of 60 Wistar rats with fatty liver were randomly divided into four normal control group, model control group, Xiaochaihu Soup treatment group [1 g/（kg · d）] and essential treatment group [64 mg/（kg · d）], with 15 in each group. We determined the effects of Xiaochaihu Soup on body mass, liver wet weight, serum alanine aminotransferase （ALT） and aspartate aminotransferase （AST）, as well as total cholesterol （TC） and triglycerides （TG） in the serum and liver tissue of nonalcoholic rat fatty liver, which were compared with those in essential treatment group. Results After treatment with Xiaochaihu Soup, the body weight and liver wet weight of rats were obviously lower than those in model group （P^0.05）~ serum ALT and AST levels as well as TC and TG contents were significantly decreased （P〈O. 05）. The therapeutic effects were similar to those in essential treatment group. Conclusion Xiaochaihu Soup can be used to treat nonalcoholic fatty liver in rats by reducing body weight and liver weight, regulating lipid metabolism, improving liver function, and reducing liver lipid deposition.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2013年第3期400-402,共3页
Journal of Xi’an Jiaotong University（Medical Sciences）
关键词
脂肪肝
小柴胡汤
大鼠
血脂
fatty liver Xiaochaihu Soup rat blood fat
