摘要
目的探讨亚低温治疗重症手足口病并发中枢性发热的疗效。方法选取2009年3月—2012年10月新乡市中心医院住院行机械通气治疗的重症手足口病并发中枢性发热患儿83例,按照随机数字表法分为对照组43例和亚低温组40例,对照组采用常规药物治疗,亚低温组采用亚低温治疗。观察两组患儿的体温变化、治疗时间及实验室检查指标等。结果对照组采用退热药物降温治疗后平均体温由(38.5±0.5)℃降至(36.8±0.3)℃,治疗时间(3.9±1.2)d;亚低温组治疗后平均肛温由(38.6±0.4)℃降至(36.9±0.3)℃,治疗时间(2.1±1.0)d。两组治疗时间比较,差异有统计学意义(t=6.958,P<0.05)。亚低温组无一例发生冻伤和低温并发症。治疗后两组血糖、血小板计数比较,差异均无统计学意义(t值分别为0.859和0.607,P>0.05)。结论亚低温治疗机械通气重症手足口病并发中枢性发热安全、有效,降温时间短,可以推广应用。
Objective To explore the effect of mild hypothermia in the treatment of severe hand - foot - mouth disease combined with central fever. Methods A total of 83 severe hand - foot - mouth disease combining central fever patients who had been treated with mechanical ventilation in the central hospital of Xinxiang from March 2009 to October 2012 were selected. According to the type of their treatment, 83 patients were divided into the control group （treated with usual agents, 43 eases） and the mild hypothermia group （treated with mild hypothermia, 40 cases） . The temperature changes, treatment time and laboratory tests of the patients were observed. Results With the usual agents treatment, the average temperature of the control group decreased from （38.5 ± 0. 5 ） ℃ to （ 36. 8 ± 0. 3 ） ℃, and treatment time was （ 3.9 ± 1.2 ） d. The average anal temperature of the mild hypothermia group decreased from （ 38.6 ± 0.4 ） ℃ to （ 36. 9 ± 0. 3 ） ℃, and treatment time was （ 2. 1 ± 1.0 ） d. Difference of treatment time between the two groups was statistically significant （ t = 6. 958, P 〈 0. 05 ） . There was no one who had frostbite and complication of hypothermia in the mild hypothermia group. No statistical significance of blood sugar and platelet counts of two groups was observed （ t value were 0. 859 and 0. 607, P 〉 0. 05 ） . Conclusion Mild hypothermia is a safe and ef- fective treatment for severe hand - foot - mouth disease complicated by central heating with auxiliary cooling therapy of mechanical ventilation, and the cooling time is short.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第12期1391-1392,共2页
Chinese General Practice
关键词
亚低温
手足口病
发热
治疗结果
Mild hypothermia
Hand, foot and mouth disease
Fever
Treatment outcome
