摘要
目的探讨脱敏联合卡介菌多糖核酸(BCG-PSN)治疗小儿支气管哮喘的疗效,以及对患儿肺部功能和血清中IgE的影响。方法选取2007年7月至2012年7月期间无锡市第八人民医院儿科门诊收治的支气管哮喘患儿120例,随机分成两组。观察组60例,在特异性脱敏治疗的基础上,加用BCG-PSN肌内注射治疗;对照组60例,进行单纯的特异性脱敏治疗,对比分析两组的治疗效果。结果治疗后,观察组患儿总有效率为96.67%,对照组患儿总有效率为78.33%,两组对比差异具有统计学意义(P<0.05);且观察组患儿在治疗起效时间、肺功能改善和血清中IgE水平均优于对照组,两组对比差异具有统计学意义(P<0.05)。结论脱敏联合BCG-PSN治疗小儿支气管哮喘具有良好的疗效,并具有起效快、缩短治疗周期和改善预后的作用。
Objective To explore the curative effect of desensitization combined with BCG - PSN in treating infantile bronchial asth- ma, and its influence on the lung function and serum IgE in children. Methods A total of 120 cases of children with asthma were admitted to the pediatric clinic of our hospital from July 2007 to July 2012, and were randomly divided into two groups： the observation group, 60 ca- ses, on the basis of specific desensitization therapy plus treatment with intramuscular injection of BCG - PSN ; the control group, 60 cases, based on a simple specific desensitization therapy. The therapeutic effect of the two groups was comparatively analysed. Results After treat- ment, the total effective rate of observation group and control group was 96.67% and 78.33% , respectively, and the difference was statisti- cally significant （ P 〈 0.05 ） ; the onset time for effectiveness, the improved function of lung and serum IgE levels in observation group were better than those in treatment group, and the difference was statistically significant （ P 〈 0.05 ）. Conclusion Desensitization combined with BCG - PSN treatment in infantile bronchial asthma has good curative effect and is currently the best combination treatment, which shortens the treatment cvcle, works fast. and imDroves the prognosis.
出处
《安徽医学》
2013年第4期443-445,共3页
Anhui Medical Journal
