摘要
近年研究表明,子痫前期的一个重要的临床特征是循环系统中血管生成因子和血管生成抑制因子的失衡。血小板反应蛋白(thrombospondin,TSP)来自多种细胞,如血小板、内皮细胞、基质纤维细胞、血管平滑肌细胞、间质细胞和免疫细胞,参与多种细胞功能,TSP有抑制血管形成的作用。TSP可能通过激活内皮细胞的增殖、迁移、黏附及浸润使内皮功能受损,进一步导致子宫螺旋动脉管腔狭窄、闭锁,引起胎盘血流灌注减少,引发子痫前期。
Recently research indicate that an imbalance of maternal circulating pro-and anti-angiogenic factors may play a role in the pathogenesis of preeclampsia. Thrombospondin （TSP） is a protein expressed in various cells such as platelet, endothelial cells ,matrix fiber cells ,vascular smooth muscle cells,interstitial cells and immunocyte ,which acts as a potent antiangiogenic agent. TSP affects several cellular functions, including proliferation, motility, adhesion, apoptosis and infiltrate make the endometrial spiral arterioles vessel tone stricture and rejection,induce placenta blood flow reduce,then induce preeclampsia.
出处
《国际妇产科学杂志》
CAS
2013年第2期126-128,133,共4页
Journal of International Obstetrics and Gynecology
