期刊文献+

小檗碱对糖尿病大鼠糖尿病心肌病的防治作用及机制 被引量:2

原文传递
导出
摘要 目的探讨小檗碱对糖尿病大鼠糖尿病心肌病的影响及机制。方法构建糖尿病大鼠模型,造模12周后考察心体比(H/B)和左室重量指数(LVMI)。结果糖尿病组大鼠H/B、LVMI增高,小檗碱给药后能降低H/B、LVMI,并具有剂量依赖性。结论小檗碱可抑制糖尿病大鼠心肌细胞外基质积聚,改善糖尿病心肌病症状。
作者 张大业
出处 《中国城乡企业卫生》 2013年第2期33-34,共2页 Chinese Journal of Urban and Rural Enterprise Hygiene
  • 相关文献

参考文献7

  • 1Seferovic Mitrovic JP, Seferovic PM, Vujisi Teaic B, et al. Predictors of diabetic cardiomyopathy in asymptomatic patients with type 2 diabetes[J].Int J Cardiol, 2012, 156(2) :219-221. 被引量:1
  • 2Barri-re DA, Rieusset J, Chanteranne D, et al. Paclitaxel therapy po- tentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization[J]. Pain, 2012, 153(3):553-561. 被引量:1
  • 3赖鹏斌,杨立勇,林旭.氟伐他汀对糖尿病大鼠心肌结缔组织生长因子表达的影响[J].中国糖尿病杂志,2006,14(3):224-226. 被引量:4
  • 4Liu X, Li G, Zhu H, et al.Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRα and PPARα transcriptional programs [J]. Endocr J, 2010, 57 ( 10 ) : 881-893. 被引量:1
  • 5Chen P, Shi Q, Xu X, et al.Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model[J]. Int J Mol Med, 2012, 30( 1 ) : 119-125. 被引量:1
  • 6Watanabe K, Thandavarayan RA, Harima M, et al. Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy[J]. Curr Cardiol Rev, 2010, 6(4):280-290. 被引量:1
  • 7Tang LQ, Wei W, Chen LM, et al. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats [J]. J Ethnopharmacol, 2006, 108( 1 ) : 109-115. 被引量:1

二级参考文献5

  • 1David S,Bell H,Face MB.Diabetic cardiomyopathy.Diabetes Care,2003,26:2949-2951. 被引量:1
  • 2Candido R,Forbes JM,Thomas MC,et al.A breaker of advance glycation end products attenuates diabetes-induced myocardial structural changes.Cir Res,2003,1892:785-792. 被引量:1
  • 3Eberlein M,Heusinger-Ribeiro J,Goppelt-Struebe M.Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG COA reductase inhibitors (statins).Br J Pharmacol,2001,133:1172-1180. 被引量:1
  • 4Stratton R,Sluwen X,Miartini G,et al.Iloprost suppresses connetive tissue growth factor production in fibroblasts and in the skin of scleroderma patients.J Clin Invest,2001,108:241-250. 被引量:1
  • 5Luo JD,Zhang WW,Zhang GP,et al.Simvastatin inhibits cardiac hypertrophy and angiotension converting enzyme activity in rats with aoutic stenosis.Clin Exp Pharmacol Physiol,1999,26:903-908. 被引量:1

共引文献3

同被引文献69

引证文献2

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部